New prognostic factor for hepatitis B virus‐related decompensated cirrhosis: Ratio of monocytes to HDL‐cholesterol

• Published in: Journal of clinical laboratory analysis 2021-11, Vol.35 (11), p.e24007-n/a
• Main Authors: Wu, Qianxia, Mao, Weilin
• Format: Article
• Language: English
• Subjects: Aged; Ascites; Biomarkers; Biomarkers - blood; Cardiovascular disease; Cholesterol; Cholesterol, HDL - blood; Cirrhosis; Creatinine; decompensated cirrhosis; Female; Hemoglobin; Hepatitis B; hepatitis B virus; High density lipoprotein; Humans; Infections; Laboratories; Liver cancer; Liver cirrhosis; Liver Cirrhosis - blood; Liver Cirrhosis - complications; Liver Cirrhosis - diagnosis; Liver Cirrhosis - mortality; Liver diseases; Liver Failure - blood; Liver Failure - diagnosis; Liver Failure - etiology; Liver Failure - mortality; Male; Medical prognosis; Middle Aged; Monocytes; Monocytes - cytology; monocyte‐to‐HDL‐cholesterol ratio; Mortality; mortality predictor; Multivariate Analysis; Nitrogen; Patients; Prognosis; Proteins; Regression analysis; Risk factors; ROC Curve
• ISSN: 0887-8013; 1098-2825
• DOI: 10.1002/jcla.24007

Aim Hepatitis B virus‐related decompensated cirrhosis (HBV‐DeCi) has a high mortality rate, and it remains a challenge to predict its outcomes in clinical practice. We aimed to determine the association between monocyte‐to‐HDL‐cholesterol ratio (MHR) and short‐term prognosis in HBV‐DeCi patients. Methods A total of 145 HBV‐DeCi patients were enrolled. A multivariate analysis was performed to identify predictors of mortality. The findings were validated by a receiver operating characteristic analysis using the area under the curve (AUC). Results A total of 20 (13.8%) patients had died 30 days after admission. MHR was markedly increased in the non‐survivors compared with the survivors. In the multivariate analysis, MHR was identified as an independent risk factor for mortality, with a significant predictive value (AUC = 0.825; sensitivity, 90.0%; specificity, 62.4%). Conclusions Elevated MHR is associated with increased mortality rate in HBV‐DeCi patients. Receiver operating characteristic curves indicating the relative efficiencies of Model for End‐stage Liver Disease score and platelet to white blood cell ratio for predicting 30‐day mortality in patients with hepatitis B virus‐associated decompensated liver cirrhosis.