Screening of Altered Metabolites and Metabolic Pathways in Celiac Disease Using NMR Spectroscopy

Background. Celiac disease (CeD) is an autoimmune intestinal disorder caused by gluten protein consumption in genetically predisposed individuals. As biopsy sampling is an invasive procedure, finding novel noninvasive serological markers for screening of at-risk CeD population is a priority. Metabol...

Full description

Saved in:
Bibliographic Details
Published in:BioMed research international 2021, Vol.2021, p.1798783-11
Main Authors: Khalkhal, Ensieh, Rezaei-Tavirani, Mostafa, Fathi, Fariba, Nobakht M. Gh, B. Fatemeh, Taherkhani, Amir, Rostami-Nejad, Mohammad, Asri, Nastaran, Haidari, Mohammad Hossain
Format: Article
Language:English
Subjects:
Adult
Autoimmune diseases
Biomarkers
Biomarkers - blood
Biopsy
Biosynthesis
Body fluids
Case-Control Studies
Celiac disease
Celiac Disease - blood
Celiac Disease - diagnosis
Celiac Disease - metabolism
Data analysis
Discriminant analysis
Female
Gastrointestinal diseases
Glutamine
Gluten
Glycine
Humans
Hydroxyisobutyric acid
Isoleucine
Leucine
Magnetic resonance spectroscopy
Magnetic Resonance Spectroscopy - methods
Male
Metabolic Networks and Pathways
Metabolic pathways
Metabolism
Metabolites
Metabolome
Metabolomics
Metabolomics - methods
Middle Aged
Multivariate analysis
Nitrogen metabolism
NMR
NMR spectroscopy
Nuclear magnetic resonance
Proteomics
Serology
Software
Spectroscopy
Statistical analysis
Statistical methods
Taurine
Threonine
tRNA
Valine
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background. Celiac disease (CeD) is an autoimmune intestinal disorder caused by gluten protein consumption in genetically predisposed individuals. As biopsy sampling is an invasive procedure, finding novel noninvasive serological markers for screening of at-risk CeD population is a priority. Metabolomics is helpful in monitoring metabolite changes in body fluids and tissues. In the present study, we evaluated serum metabolite levels of CeD patients relative to healthy controls with the aim of introducing new biomarkers for population screening. Method. We compared the serum metabolic profile of CeD patients (n=42) and healthy controls (n=22) using NMR spectroscopy and multivariate analysis. Result. 25 metabolites were identified by serum metabolic profiling. Levels of 3-hydroxyisobutyric acid and isobutyrate showed significant differences in CeD patients’ samples compared with healthy controls (p
ISSN:2314-6133
2314-6141
DOI:10.1155/2021/1798783