Efficiency of resveratrol in the prevention and treatment of age‑related hearing loss

Age-related hearing loss (ARHL) is a major public health concern, which is characterized by gradual, progressive sensorineural hearing loss and deterioration of sound localization, with no effective treatment available to date. The aim of the present study was to evaluate the efficacy of resveratrol...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2022-01, Vol.23 (1), Article 40
Main Authors: Muderris, Togay, Saglam, Atiye Seda Yar, Unsal, Dondu, Mulazimoglu, Selquk, Sevil, Ergun, Kayhan, Handan
Format: Article
Language:English
Subjects:
Age
Aging
Anesthesia
Apoptosis
Care and treatment
Development and progression
Drinking water
Ears & hearing
Electrodes
Free radicals
Gene expression
Health aspects
Hearing loss
Laboratory animals
Older people
Oxidative stress
Polyphenols
Production increases
Resveratrol
Software
Statistical analysis
Thermal cycling
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Summary:Age-related hearing loss (ARHL) is a major public health concern, which is characterized by gradual, progressive sensorineural hearing loss and deterioration of sound localization, with no effective treatment available to date. The aim of the present study was to evaluate the efficacy of resveratrol to prevent and treat ARHL. For this purpose, 32 male C57BL/6 mice were assigned to four groups: Early treatment, late treatment, control and sham control. The experiment lasted for 15 months. Treatment was started at three months of age in the early treatment group and at sixth months in the late treatment group. The auditory brainstem response test was performed once every three months. At the end of the study period, inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, NF-[kappa]B, Bcl-2, Bcl-xL, Bax, Bcl-2 homologous antagonist/killer (Bak), caspase-3 and caspase-9 levels in the cochlear tissues of the animals were analyzed by reverse transcription-quantitative PCR. Hearing thresholds of the mice in the early treatment group were better than those in the other groups (P0.05), although mean thresholds were lower. The threshold shift in the early treatment group was significantly lower at all frequencies when compared with those in the control groups (P
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2021.10962