Cardiac Biomarkers in Pediatrics: An Undervalued Resource

• Published in: Clinical chemistry (Baltimore, Md.) Md.), 2021-07, Vol.67 (7), p.947-958
• Main Authors: Bohn, Mary Kathryn, Steele, Shannon, Hall, Alexandra, Poonia, Jasmin, Jung, Benjamin, Adeli, Khosrow
• Format: Article
• Language: English
• Subjects: Acute coronary syndromes; Age; Biological markers; Biomarkers; Brain natriuretic peptide; Cardiovascular diseases; Children; Congestive heart failure; Coronary artery disease; Decision making; Diagnosis; Heart diseases; Heart failure; Myocarditis; Neonates; Pediatric research; Pediatrics; Peptides; Physiological aspects; Populations; Review
• ISSN: 0009-9147; 1530-8561
• DOI: 10.1093/clinchem/hvab063

Abstract Background The clinical use of common cardiac biomarkers, such as brain natriuretic peptides and troponins, has traditionally been limited to adult populations in the assessment of heart failure and acute coronary syndrome, respectively. While many have discounted the value of these markers in pediatric populations, emerging evidence suggests they may be useful in the diagnosis and prognostication of many cardiac and noncardiac pathologies in neonates, children, and adolescents, and an increasing number of pediatric hospitals are routinely measuring cardiac markers in their clinical practice. Content This review summarizes and critically evaluates the current literature regarding the application of cardiac biomarkers for clinical decision-making in the pediatric population. Main potential clinical indications discussed herein include primary cardiac disease, immune-related conditions, and noncardiac disease. Important diagnostic and interpretative challenges are also described in relation to each potential indication. Summary Despite a general lack of clinical awareness regarding the value of cardiac biomarkers in pediatrics, there is increasing literature to support their application in various contexts. Cardiac biomarkers should be considered an undervalued resource in the pediatric population with potential value in the diagnosis and prognosis of myocarditis, congenital heart disease, and heart failure, as well as in the assessment of severity and cardiac involvement in immune-related and other systemic conditions. While interpretation remains challenging in pediatrics due to the age- and sex-specific dynamics occurring throughout growth and development, this should not prevent their application. Future research should focus on defining evidence-based cut-offs for specific indications using the most up-to-date assays.