Associations of cardiovascular risk factors with survival outcomes in a cancer registration: Findings from the KUMAMON registry

Although the relationship between cardiovascular diseases and malignant diseases has recently attracted attention, the associations of cardiovascular risk factors and clinical outcomes in cancer patients remain to be elucidated. We performed a retrospective, observational study that explored the cli...

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Published in:Medicine (Baltimore) 2021-11, Vol.100 (47), p.e27921-e27921
Main Authors: Maki, Yuji, Sueta, Daisuke, Ishii, Masanobu, Yamanouchi, Yoshinori, Fujisue, Koichiro, Yamanaga, Kenshi, Nakamura, Taishi, Tabata, Noriaki, Arima, Yuichiro, Araki, Satoshi, Yamamoto, Eiichiro, Kaikita, Koichi, Chikamoto, Akira, Matsushita, Kenichi, Matsuoka, Masao, Usuku, Koichiro, Tsujita, Kenichi
Format: Article
Language:English
Subjects:
Aged
Cardiovascular Diseases - epidemiology
Diabetes Mellitus - epidemiology
Dyslipidemias - epidemiology
Female
Heart Disease Risk Factors
Humans
Hypertension - epidemiology
Kaplan-Meier Estimate
Male
Middle Aged
Morbidity
Neoplasms - mortality
Neoplasms - pathology
Observational Study
Registries
Retrospective Studies
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Summary:Although the relationship between cardiovascular diseases and malignant diseases has recently attracted attention, the associations of cardiovascular risk factors and clinical outcomes in cancer patients remain to be elucidated. We performed a retrospective, observational study that explored the clinical outcomes of patients with cancer or with a history of cancer.We enrolled 30,706 consecutive adult cancer patients from Kumamoto University Hospital. We investigated mortality and morbidity, including cardiovascular conditions (dyslipidemia [DL]/diabetes mellitus [DM]/hypertension [HT]). The primary endpoint was all-cause mortality.Of the enrolled patients, 9032 patients (29.4%) died within the follow-up period. The Kaplan-Meier analysis demonstrated that in the groups classified according to the number of DL/DM/HT (LDH) factors, the LDH1 and LDH2 groups had a significantly higher probability of the primary endpoint than the LDH0 group (P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000027921