Dysregulation of Translation Factors EIF2S1, EIF5A and EIF6 in Intestinal-Type Adenocarcinoma (ITAC)

Intestinal-type adenocarcinoma (ITAC) is a rare cancer of the nasal cavity and paranasal sinuses that occurs sporadically or secondary to exposure to occupational hazards, such as wood dust and leather. Eukaryotic translation initiation factors have been described as promising targets for novel canc...

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Bibliographic Details
Published in:Cancers 2021-11, Vol.13 (22), p.5649
Main Authors: Schatz, Christoph, Sprung, Susanne, Schartinger, Volker, Codina-Martínez, Helena, Lechner, Matt, Hermsen, Mario, Haybaeck, Johannes
Format: Article
Language:English
Subjects:
Adenocarcinoma
Antibodies
Cancer
Datasets
Dust
Ethics
Gene expression
Initiation factor eIF-6
Initiation factors
Intestine
Leather
Metastasis
Neoplasia
Nose
Occupational exposure
Occupational hazards
Paranasal sinus
Patients
Radiation therapy
Sinus
Survival
Therapeutic applications
Therapeutic targets
Tumors
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Summary:Intestinal-type adenocarcinoma (ITAC) is a rare cancer of the nasal cavity and paranasal sinuses that occurs sporadically or secondary to exposure to occupational hazards, such as wood dust and leather. Eukaryotic translation initiation factors have been described as promising targets for novel cancer treatments in many cancers, but hardly anything is known about these factors in ITAC. Here we performed in silico analyses, evaluated the protein levels of EIF2S1, EIF5A and EIF6 in tumour samples and non-neoplastic tissue controls obtained from 145 patients, and correlated these results with clinical outcome data, including tumour site, stage, adjuvant radiotherapy and survival. In silico analyses revealed significant upregulation of the translation factors EIF6 (ITGB4BP), EIF5, EIF2S1 and EIF2S2 (p < 0.05) with a higher arithmetic mean expression in ITAC compared to non-neoplastic tissue (NNT). Immunohistochemical analyses using antibodies against EIF2S1 and EIF6 confirmed a significantly different expression at the protein level (p < 0.05). In conclusion, this work identifies the eukaryotic translation initiation factors EIF2S1 and EIF6 to be significantly upregulated in ITAC. As these factors have been described as promising therapeutic targets in other cancers, this work identifies candidate therapeutic targets in this rare but often deadly cancer.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers13225649