Chronic Recurrent Multifocal Osteomyelitis Associated with Crohn Disease: A Potential Role of Exclusion Diet? Comment on Starz et al. The Modification of the Gut Microbiota via Selected Specific Diets in Patients with Crohn's Disease. Nutrients 2021, 13 , 2125

The efficacy of diet and its influence on gut microbiome composition has been largely demonstrated in inflammatory bowel disease (IBD). Little is known about its potential in the management of extraintestinal manifestations. We report a successful application of Crohn disease exclusion diet (CDED) i...

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Bibliographic Details
Published in:Nutrients 2021-11, Vol.13 (11), p.4005
Main Authors: Cantarelli, Erika, Baccelli, Francesco, Simonini, Gabriele, Alvisi, Patrizia
Format: Article
Language:English
Subjects:
Biomedical materials
Child
Chronic Disease
Comment
Conflicts of interest
Crohn Disease - complications
Crohn's disease
Diet
Digestive system
Enteral nutrition
Gastrointestinal Microbiome - physiology
Humans
Inflammatory bowel disease
Inflammatory bowel diseases
Inflammatory Bowel Diseases - complications
Infliximab
Informed consent
Intestinal microflora
Intestine
Magnetic resonance imaging
Methotrexate
Microbiomes
Microbiota
Monoclonal antibodies
Nutrients
Nutrition
Osteomyelitis
Osteomyelitis - complications
Pathogenesis
Patients
Pediatrics
Remission (Medicine)
Signs and symptoms
Tumor necrosis factor-α
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Summary:The efficacy of diet and its influence on gut microbiome composition has been largely demonstrated in inflammatory bowel disease (IBD). Little is known about its potential in the management of extraintestinal manifestations. We report a successful application of Crohn disease exclusion diet (CDED) in association with infliximab and methotrexate, as salvage therapy in a child affected by chronic recurrent multifocal osteomyelitis (CRMO) and Crohn disease (CD) resistant to optimized therapy. Both intestinal and bone symptoms remitted after the application of CDED. Diet may have acted on common microbic inciting agents that trigger both intestinal and bone inflammation, supporting the role of microbiota in the pathogenesis of IBD-associated extraintestinal manifestations. Our experience suggests the potential benefit of CDED in association with combined therapy in resistant patients affected by CD and extraintestinal manifestations.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu13114005