Statistical Analysis of the Main Risk Factors of an Unfavorable Evolution in Gastroschisis

Gastroschisis is a congenital abdominal wall defect that presents an increasing occurrence at great cost for the health system. The aim of the study is to detect the main factors of an unfavorable evolution in the case of gastroschisis and to find the best predictors of death. Methods: we conducted...

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Bibliographic Details
Published in:Journal of personalized medicine 2021-11, Vol.11 (11), p.1168
Main Authors: Ţarcă, Elena, Roșu, Solange Tamara, Cojocaru, Elena, Trandafir, Laura, Luca, Alina Costina, Lupu, Valeriu Vasile, Moisă, Ștefana Maria, Munteanu, Valentin, Butnariu, Lăcrămioara Ionela, Ţarcă, Viorel
Format: Article
Language:English
Subjects:
Abdomen
Abdominal wall
Apgar score
Birth weight
Bronchopneumonia
Compartment syndrome
Death
Evolution
Hospitals
Morbidity
Mortality
Neonates
Pediatrics
Precision medicine
Prenatal care
Risk factors
Sepsis
Statistical analysis
Surgery
Variables
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Summary:Gastroschisis is a congenital abdominal wall defect that presents an increasing occurrence at great cost for the health system. The aim of the study is to detect the main factors of an unfavorable evolution in the case of gastroschisis and to find the best predictors of death. Methods: we conducted a retrospective cohort study of neonates with gastroschisis treated in a tertiary pediatric center during the last 30 years; 159 patients were eligible for the study. Logistic regression was used to determine the risk of death, estimated based on independent variables previously validated by the chi-square test. Results: if the birth weight is below normal, then we find an increased risk (4.908 times) of evolution to death. Similarly, the risk of death is 7.782 times higher in the case of developing abdominal compartment syndrome, about 3 times in the case of sepsis and 7.883 times in the case of bronchopneumonia. All four independent variables contributed 47.6% to the risk of death. Conclusion: although in the past 30 years in our country we have seen transformational improvements in outcome of gastroschisis, survival rates increasing from 26% to 52%, some factors may still be ameliorated for a better outcome.
ISSN:2075-4426
2075-4426
DOI:10.3390/jpm11111168