The 2-Year Leakage Index and Quantitative Microaneurysm Results of the RECOVERY Study: Quantitative Ultra-Widefield Findings in Proliferative Diabetic Retinopathy Treated with Intravitreal Aflibercept

Eyes with proliferative diabetic retinopathy (PDR) have been shown to improve in the leakage index and microaneurysm (MA) count after intravitreal aflibercept (IAI) treatment. The authors investigated these changes via automatic segmentation on ultra-widefield fluorescein angiography (UWFA). Forty s...

Full description

Saved in:
Bibliographic Details
Published in:Journal of personalized medicine 2021-11, Vol.11 (11), p.1126
Main Authors: Babiuch, Amy S, Wykoff, Charles C, Yordi, Sari, Yu, Hannah, Srivastava, Sunil K, Hu, Ming, Le, Thuy K, Lunasco, Leina, Reese, Jamie, Nittala, Muneeswar G, Sadda, SriniVas R, Ehlers, Justis P
Format: Article
Language:English
Subjects:
Angiography
Automation
Diabetes
Diabetes mellitus
Diabetic retinopathy
Edema
Fluorescein
Ischemia
Leakage
Medical imaging
Precision medicine
Retina
Retinopathy
Segmentation
Statistical analysis
Vascular endothelial growth factor
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Eyes with proliferative diabetic retinopathy (PDR) have been shown to improve in the leakage index and microaneurysm (MA) count after intravitreal aflibercept (IAI) treatment. The authors investigated these changes via automatic segmentation on ultra-widefield fluorescein angiography (UWFA). Forty subjects with PDR were randomized to receive either 2 mg IAI every 4 weeks (Arm 1) or every 12 weeks (Arm 2) through Year 1. After Year 1, Arm 1 switched to quarterly IAI and Arm 2 to monthly IAI through Year 2. By Year 2, the Arm 1 leakage index decreased by 43% from Baseline ( = 0.03) but increased by 59% from Year 1 ( = 0.04). Arm 2 decreased by 61% from Baseline ( = 0.008) and by 31% from Year 1 ( = 0.12). Both cohorts exhibited a significant decline in MAs from Baseline to Year 2 (871 to 410; < 0.001; 776 to 207; < 0.001, respectively). Subjects with an improved leakage and MA count showed a more significant improvement in the Diabetic Retinopathy Severity Scale (DRSS) score. Moreover, central subfield thickness (CST) was positively associated with changes in the leakage index. In conclusion, the leakage index and MA counts significantly improved from Baseline following IAI treatment, and monthly injections provided a more rapid and sustained reduction in these parameters compared with quarterly injections.
ISSN:2075-4426
2075-4426
DOI:10.3390/jpm11111126