Preliminary Study on the Simulation of a Radiation Damage Analysis of Biodegradable Polymers

In this study, biodegradable poly(L-lactide-co-ε-caprolactone) (PLCL) and poly(L-co-d,l lactide) (PLDLA) were evaluated using Geant4 (G4EmStandardPhysics_option4) for damage simulation, in order to predict the safety of these biodegradable polymers against gamma ray sterilization. In the PLCL damage...

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Bibliographic Details
Published in:Materials 2021-11, Vol.14 (22), p.6777
Main Authors: Shim, Ha-Eun, Yeon, Yeong-Heum, Lim, Dae-Hee, Nam, You-Ree, Park, Jin-Hyung, Lee, Nam-Ho, Gwon, Hui-Jeong
Format: Article
Language:English
Subjects:
Biodegradability
Biodegradation
Chain scission
Cleavage
Computer simulation
Crosslinking
Damage assessment
Decomposition
Fourier transforms
Gamma rays
Infrared analysis
Infrared reflection
Liquid chromatography
Medical equipment
Molecular weight
Physical properties
Polyesters
Polymers
Radiation
Radiation damage
Radiation dosage
Radiation effects
Safety
Simulation
Sterilization
Viscosity
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Summary:In this study, biodegradable poly(L-lactide-co-ε-caprolactone) (PLCL) and poly(L-co-d,l lactide) (PLDLA) were evaluated using Geant4 (G4EmStandardPhysics_option4) for damage simulation, in order to predict the safety of these biodegradable polymers against gamma ray sterilization. In the PLCL damage model, both chain scission and crosslinking reactions appear to occur at a radiation dose in the range 0–200 kGy, but the chain cleavage reaction is expected to be relatively dominant at high irradiation doses above 500 kGy. On the other hand, the PLDLA damage model predicted that the chain cleavage reaction would prevail at the total irradiation dose (25–500 kGy). To verify the simulation results, the physicochemical changes in the irradiated PLCL and PLDLA films were characterized by GPC (gel permeation chromatography), ATR-FTIR (attenuated total reflection Fourier transform infrared), and DSC (difference scanning calorimetry) analyses. The Geant4 simulation curve for the radiation-induced damage to the molecular weight was consistent with the experimentally obtained results. These results imply that the pre-simulation study can be useful for predicting the optimal irradiation dose and ensuring material safety, particularly for implanted biodegradable materials in radiation processing.
ISSN:1996-1944
1996-1944
DOI:10.3390/ma14226777