Low Tumor-to-Stroma Ratio Reflects Protective Role of Stroma against Prostate Cancer Progression

Tumor-to-stroma ratio (TSR) is a prognostic factor that expresses the relative amounts of tumor and intratumoral stroma. In this study, its clinical and molecular relevance was evaluated in prostate cancer (PCa). The feasibility of automated quantification was tested in digital scans of tissue micro...

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Bibliographic Details
Published in:Journal of personalized medicine 2021-10, Vol.11 (11), p.1088
Main Authors: Nastały, Paulina, Smentoch, Julia, Popęda, Marta, Martini, Emanuele, Maiuri, Paolo, Żaczek, Anna J, Sowa, Marek, Matuszewski, Marcin, Szade, Jolanta, Kalinowski, Leszek, Niemira, Magdalena, Brandt, Burkhard, Eltze, Elke, Semjonow, Axel, Bednarz-Knoll, Natalia
Format: Article
Language:English
Subjects:
Age
Automation
Breast cancer
Cell adhesion & migration
Cell adhesion molecules
DNA microarrays
Epithelial cells
Extracellular matrix
Gene expression
Medical prognosis
Multivariate analysis
Pathology
Patients
Precision medicine
Prostate cancer
Stroma
Survival analysis
Transcription factors
Tumors
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Summary:Tumor-to-stroma ratio (TSR) is a prognostic factor that expresses the relative amounts of tumor and intratumoral stroma. In this study, its clinical and molecular relevance was evaluated in prostate cancer (PCa). The feasibility of automated quantification was tested in digital scans of tissue microarrays containing 128 primary tumors from 72 PCa patients stained immunohistochemically for epithelial cell adhesion molecule (EpCAM), followed by validation in a cohort of 310 primary tumors from 209 PCa patients. In order to investigate the gene expression differences between tumors with low and high TSR, we applied multigene expression analysis (nCounter PanCancer Progression Panel, NanoString) of 42 tissue samples. TSR scores were categorized into low (
ISSN:2075-4426
2075-4426
DOI:10.3390/jpm11111088