Characterization and Topical Study of Aloe Vera Hydrogel on Wound-Healing Process

Wound healing is fundamental to restore the tissue integrity. A topical study of the influence of Aloe vera hydrogel, formulated with 1,2-propanediol (propanediol) and triethanolamine (TEA), on the skin wound-healing process was investigated in female Wistar rats. FTIR spectroscopy confirms the pres...

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Bibliographic Details
Published in:Polymers 2021-11, Vol.13 (22), p.3958
Main Authors: Meza-Valle, Karen Zulema, Saucedo-Acuña, Rosa Alicia, Tovar-Carrillo, Karla Lizzette, Cuevas-González, Juan Carlos, Zaragoza-Contreras, Erasto Armando, Melgoza-Lozano, Juana
Format: Article
Language:English
Subjects:
Aloe
Biopsy
Carboxylic acids
Contact angle
Cosmetics
Fourier transforms
Growth factors
Hydrogels
In vivo methods and tests
Microscopy
Pharmaceutical industry
Skin
Tissue engineering
Triethanolamine
Vagina
Wound healing
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Summary:Wound healing is fundamental to restore the tissue integrity. A topical study of the influence of Aloe vera hydrogel, formulated with 1,2-propanediol (propanediol) and triethanolamine (TEA), on the skin wound-healing process was investigated in female Wistar rats. FTIR spectroscopy confirms the presence of carboxylic acid and methyl ester carboxylate groups related with important compounds that confer the hydrogel a good interaction with proteins and growth factors. SEM images show a microstructure and micro-roughness that promote a good adhesion to the wound. Therefore, the swelling kinetics and the contact angle response contribute to the understanding of the in vivo results of the animal test. The results indicated that the Aloe vera hydrogel, prepared with propanediol and TEA, together with its superficial characteristics, improve its rapid penetration without drying out the treated tissue. This produced a positive influence on inflammation, angiogenesis, and wound contraction, reducing 29% the total healing time, reaching the total closure of the wound in 15 days.
ISSN:2073-4360
2073-4360
DOI:10.3390/polym13223958