A Rare Case of Waldenstrom Macroglobulinemia of the Rectosigmoid Colon

Waldenstrom macroglobulinemia is an uncommon mature B-cell lymphoma characterized by monoclonal immunoglobulin M protein in peripheral blood and lymphoplasmacytic cells in bone marrow and/or extramedullary sites. The gastrointestinal tract is a rare site of involvement. The diagnosis is based on cli...

Full description

Saved in:
Bibliographic Details
Published in:ACG case reports journal 2021-11, Vol.8 (11), p.e00689-e00689
Main Authors: Zelman, Sara, Russell, Michael B., Hojat, Amin, Pilichowska, Monika, Olans, Lori B., Sterling, Mark J.
Format: Article
Language:English
Subjects:
Case Report
Colon
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Waldenstrom macroglobulinemia is an uncommon mature B-cell lymphoma characterized by monoclonal immunoglobulin M protein in peripheral blood and lymphoplasmacytic cells in bone marrow and/or extramedullary sites. The gastrointestinal tract is a rare site of involvement. The diagnosis is based on clinicopathologic findings, although somatic mutations, such as MYD88, can aid in the diagnosis. We present a patient with irregular stools diagnosed with Waldenstrom macroglobulinemia involving the rectosigmoid colon by histopathology and immunohistochemistry on colonic biopsies, immunoglobulin M protein in serum, clonal plasma cells in bone marrow, and MYD88 mutation in colonic and bone marrow specimens.
ISSN:2326-3253
2326-3253
DOI:10.14309/crj.0000000000000689