Efficacy of Regional Chemotherapy Approach in Peritoneal Metastatic Gastric Cancer

Peritoneal spread is frequent in gastric cancer (GC) and a palliative condition. After failure to systemic chemotherapy (sCTx) remaining therapeutic options are very limited. We evaluated the feasibility and efficacy of locoregional chemotherapy (RegCTx) in peritoneal metastatic GC. In total, 38 (23...

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Bibliographic Details
Published in:Journal of clinical medicine 2021-11, Vol.10 (22), p.5322
Main Authors: Aigner, Kornelia, Vashist, Yogesh Kumar, Selak, Emir, Gailhofer, Sabine, Aigner, Karl Reinhard
Format: Article
Language:English
Subjects:
Abdomen
Catheters
Chemotherapy
Clinical medicine
Coronary vessels
Cytotoxicity
Diaphragm (Anatomy)
Drug dosages
Gastric cancer
Hypoxia
Metastasis
Patients
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Summary:Peritoneal spread is frequent in gastric cancer (GC) and a palliative condition. After failure to systemic chemotherapy (sCTx) remaining therapeutic options are very limited. We evaluated the feasibility and efficacy of locoregional chemotherapy (RegCTx) in peritoneal metastatic GC. In total, 38 (23 male and 15 female) patients with peritoneal metastatic GC after failure of previous sCTx and unresectable disease were enrolled in this study. Using the hypoxic abdominal stop-flow perfusion, upper abdominal perfusion and intraarterial infusion technique in total 114 cycles with Cisplatin, Adriamycin and Mitomycin C were applied. No significant procedure related toxicity was noticed- especially no Grade 3 or 4 toxicity occurred. With the RegCTx approach a median overall survival of 17.4 months was achieved. Patients who had undergone previously resection of the GC the median overall survival was even better with 23.5 months. RegCTx is a promising, safe and efficient approach in diffuse metastatic GC. The evaluation of RegCTx in the setting of multimodal treatment approach at less advanced stages is also warranted.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm10225322