Effects of a Heated Anesthesia Breathing Circuit on Body Temperature in Anesthetized Rhesus Macaques (Macaca mulatta)

• Published in: Journal of the American Association for Laboratory Animal Science 2021-11, Vol.60 (6), p.675-680
• Main Authors: Bowling, Philip A, Bencivenga, Michael A, Leyva, Mary E, Grego, Briittnee E, Cornelius, Robin N, Cornelius, Emily M, Cover, Chase D, Gonzales, Chase A, Fetterer, David P, Reiter, Cara P
• Format: Article
• Language: English
• Subjects: Anesthesia - veterinary; Anesthetics, Inhalation; Animals; Body Temperature; Body Temperature Regulation; Hot Temperature; Hypothermia; Macaca mulatta; Male; Original Research
• ISSN: 1559-6109
• DOI: 10.30802/AALAS-JAALAS-21-000058

This study evaluated the effects of using a heated anesthesia breathing circuit in addition to forced-air warming on bodytemperature in anesthetized rhesus macaques as compared with forced-air warming alone. Hypothermia is a common perianestheticand intraoperative complication that can increase the risk of negative outcomes. Body heat is lost through 4 mechanisms during anesthesia: radiation, conduction, convection, and evaporation. Typical warming methods such as forced-air warming devices, conductive heating pads, and heated surgical tables only influence radiative and conductive mechanisms of heatloss. A commercially available heated breathing circuit that delivers gas warmed to 104 °F can easily be integrated into ananesthesia machine. We hypothesized that heating the inspired anesthetic gas to address the evaporative mechanism of heatloss would result in higher body temperature during anesthesia in rhesus macaques. Body temperatures were measured at 5-min intervals in a group of 10 adult male rhesus macaques during 2 anesthetic events: one with a heated anesthesia breathing circuit in addition to forced-air warming, and one with forced-air warming alone. The addition of a heated breathing circuit had a significant positive effect on perianesthetic body temperature, with a faster return to baseline temperature, earlier nadir of initial drop in body temperature, and higher body temperatures during a 2-h anesthetic procedure. Use of a heated anesthesia breathing circuit should be considered as a significant refinement to thermal support during macaque anesthesia, especially for procedures lasting longer than one hour.