Long-Term Carbohydrate-Containing Late-Evening Snack Significantly Improves the Ratio of Branched Chain Amino Acids to Aromatic Amino Acids in Adults with Liver Cirrhosis due to Hepatitis B

Background. The liver is the primary organ for amino acid metabolism, and metabolic disorder of amino acids is common in liver disease. However, the characteristics of plasma amino acid profiles in patients with HBV-related cirrhosis and the impacts of late-evening snack (LES) on cirrhosis are uncle...

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Bibliographic Details
Published in:BioMed research international 2021, Vol.2021 (1), p.1074565-1074565
Main Authors: Hou, Wei, Lv, Zheng, Yang, Jing, Wu, Jing, Wang, Zhong-ying, Meng, Qing-hua
Format: Article
Language:English
Subjects:
Adult
Age
Amino acid sequence
Amino acids
Amino Acids, Aromatic - blood
Amino Acids, Branched-Chain - blood
Ammonia
Ammonia - blood
Carbohydrates
Case-Control Studies
Chain branching
Chains
Cirrhosis
Creatinine
Dietary Carbohydrates - administration & dosage
Energy
Female
Glutamine
Glutamine - blood
Glycine
Hemoglobin
Hepatitis
Hepatitis B
Hepatitis B, Chronic - blood
Hepatitis B, Chronic - complications
Hepatitis B, Chronic - diet therapy
Humans
Infections
Interferon
Laboratories
Liver
Liver cancer
Liver cirrhosis
Liver Cirrhosis - blood
Liver Cirrhosis - diet therapy
Liver Cirrhosis - etiology
Liver diseases
Male
Medical prognosis
Metabolic disorders
Metabolism
Methionine
Middle Aged
Nutrition
Patients
Phenylalanine
Plasma
Proteins
Snacks
Supplements
Threonine
Tyrosine
Variance analysis
Viral infections
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Summary:Background. The liver is the primary organ for amino acid metabolism, and metabolic disorder of amino acids is common in liver disease. However, the characteristics of plasma amino acid profiles in patients with HBV-related cirrhosis and the impacts of late-evening snack (LES) on cirrhosis are unclear. Objectives. To investigate the characteristics of plasma amino acid profiles in patients with HBV-related chronic hepatitis, cirrhosis, and the effects of late-evening snacks on plasma amino acid profiles. Methods. 86 patients with HBV-related cirrhosis and eighty patients with chronic hepatitis B were included in this study. The plasma amino acid profiles were measured by the amino acid analyzer. Patients were randomly divided into two groups, of which the liver cirrhosis group was to receive daily LES (n=43) or non-LES (n=43) for 6 months. Plasma amino acid profiles and biochemical parameters were measured in both groups at baseline and after 1, 3, and 6 months. Results. Compared to healthy controls, the plasma concentration in the liver cirrhosis group of threonine, serine, glycine, glutamine, cysteine, tyrosine, phenylalanine, arginine, and methionine increased significantly (P
ISSN:2314-6133
2314-6141
DOI:10.1155/2021/1074565