Zinc status and growth in infants and young children with cystic fibrosis

Background Zinc deficiency is associated with poor growth in children without cystic fibrosis (CF), but its impact on growth in children with CF is unknown. Objective To determine the prevalence of low serum Zn (sZn) and its relationship with growth in the first 3 years of life in children with CF....

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Bibliographic Details
Published in:Pediatric pulmonology 2021-12, Vol.56 (12), p.3768-3776
Main Authors: Bauer, Sarah E., Lai, HuiChuan J., McDonald, Catherine M., Asfour, Fadi, Slaven, James E., Ren, Clement L.
Format: Article
Language:English
Subjects:
Child
Child, Preschool
Cross-Sectional Studies
Cystic Fibrosis
growth
Humans
Infant
Longitudinal Studies
nutrition
Nutritional Status
Zinc
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Summary:Background Zinc deficiency is associated with poor growth in children without cystic fibrosis (CF), but its impact on growth in children with CF is unknown. Objective To determine the prevalence of low serum Zn (sZn) and its relationship with growth in the first 3 years of life in children with CF. Methods We utilized data from infants with CF who were enrolled in a longitudinal study of nutrition and lung health and had sZn measured as part of clinical care. Cross‐sectional correlations between sZn levels and growth z scores were assessed by Pearson's correlation coefficient. To identify factors associated with sZn status and its association to longitudinal growth patterns, multiple regression analysis with repeated measures were performed using generalized estimating equations. Results A total of 106 sZn measurements from 53 infants were identified. Seventeen infants (32%) had intermittent Zn insufficiency, defined as at least one sZn
ISSN:8755-6863
1099-0496
DOI:10.1002/ppul.25666