The effect of metformin on body mass index and metabolic parameters in non-diabetic HIV-positive patients: a meta-analysis

We sought to evaluate the effetc of metformin on body mass index (BMI) and metabolic parameters in HIV-positive patients. We performed a comprehensive search through five major indexing databases, using keywords (“metformin” OR “dimethylguanylguanidine” OR “biguanide” OR  “ Glucophage”) AND (“HIV” O...

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Bibliographic Details
Published in:Journal of diabetes and metabolic disorders 2021-08, Vol.20 (2), p.1901-1911
Main Authors: Harmooshi, Narges Nazari, abeshtan, Ahmad, Zakerkish, Mehrnoush, Mirmomeni, Golshan, Rahim, Fakher
Format: Article
Language:English
Subjects:
Body mass index
Comparative analysis
Dextrose
Diabetes
Endocrinology
Glucose
HIV (Viruses)
HIV patients
Low density lipoproteins
Medicine
Medicine & Public Health
Metabolic Diseases
Metformin
Review
Review Article
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Summary:We sought to evaluate the effetc of metformin on body mass index (BMI) and metabolic parameters in HIV-positive patients. We performed a comprehensive search through five major indexing databases, using keywords (“metformin” OR “dimethylguanylguanidine” OR “biguanide” OR  “ Glucophage”) AND (“HIV” OR “human immunodeficiency virus” OR “AIDS” OR “Acquired immunodeficiency syndrome”), and all possible combinations until January 15, 2021. We measured standardized mean differences (SMD) and 95% confidence intervals (CI) for each outcome. We finally included 12 RCTs (577 participants, 274 in the metformin group and 303 in the comparators). Metformin did not significantly change BMI index compared to various comparators. Metformin generally improve LDL levels (SMD = 0.29, 95% CI: − 1.00 1.57,  P  = 0.01), HDL levels (SMD = − 0.15, 95% CI: − 0.72 0.41,  P  = 0.001), triglycerides values (SMD = 0.46, 95% CI: − 0.36 1.27,  P  
ISSN:2251-6581
2251-6581
DOI:10.1007/s40200-021-00869-1