Visual percepts evoked with an intracortical 96-channel microelectrode array inserted in human occipital cortex

• Published in: The Journal of clinical investigation 2021-12, Vol.131 (23)
• Main Authors: Fernández, Eduardo, Alfaro, Arantxa, Soto-Sánchez, Cristina, Gonzalez-Lopez, Pablo, Lozano, Antonio M, Peña, Sebastian, Grima, Maria Dolores, Rodil, Alfonso, Gómez, Bernardeta, Chen, Xing, Roelfsema, Pieter R, Rolston, John D, Davis, Tyler S, Normann, Richard A
• Format: Article
• Language: English
• Subjects: Analysis; Blindness; Blindness - surgery; Care and treatment; Clinical Medicine; Electric Stimulation - methods; Electrodes, Implanted; Female; Humans; Implants, Artificial; Microelectrodes; Middle Aged; Occipital Lobe - physiopathology; Occipital Lobe - surgery; Optic Nerve Diseases - surgery; Patient outcomes; Phosphenes; Prosthesis; Retina - physiology; Treatment Outcome; Vision, Ocular; Visual Cortex - physiopathology; Visual Cortex - surgery; Visual Perception; Visual Prosthesis
• ISSN: 1558-8238; 0021-9738; 1558-8238
• DOI: 10.1172/JCI151331

BACKGROUNDA long-held goal of vision therapy is to transfer information directly to the visual cortex of blind individuals, thereby restoring a rudimentary form of sight. However, no clinically available cortical visual prosthesis yet exists.METHODSWe implanted an intracortical microelectrode array consisting of 96 electrodes in the visual cortex of a 57-year-old person with complete blindness for a 6-month period. We measured thresholds and the characteristics of the visual percepts elicited by intracortical microstimulation.RESULTSImplantation and subsequent explantation of intracortical microelectrodes were carried out without complications. The mean stimulation threshold for single electrodes was 66.8 ± 36.5 μA. We consistently obtained high-quality recordings from visually deprived neurons and the stimulation parameters remained stable over time. Simultaneous stimulation via multiple electrodes was associated with a significant reduction in thresholds (P < 0.001, ANOVA) and evoked discriminable phosphene percepts, allowing the blind participant to identify some letters and recognize object boundaries.CONCLUSIONSOur results demonstrate the safety and efficacy of chronic intracortical microstimulation via a large number of electrodes in human visual cortex, showing its high potential for restoring functional vision in the blind.TRIAL REGISTRATIONClinicalTrials.gov identifier NCT02983370.FUNDINGThe Spanish Ministerio de Ciencia Innovación y Universidades, the Generalitat Valenciana (Spain), the Europan Union's Horizon 2020 programme, the Bidons Egara Research Chair of the University Miguel Hernández (Spain), and the John Moran Eye Center of the University of Utah.