The distinct roles of zinc finger CCHC-type (ZCCHC) superfamily proteins in the regulation of RNA metabolism

The zinc finger CCHC-type (ZCCHC) superfamily proteins, characterized with the consensus sequence C-X 2 -C-X 4 -H-X 4 -C, are accepted to have high-affinity binding to single-stranded nucleic acids, especially single-stranded RNAs. In human beings 25 ZCCHC proteins have been annotated in the HGNC da...

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Bibliographic Details
Published in:RNA biology 2021-12, Vol.18 (12), p.2107-2126
Main Authors: Wang, Yishu, Yu, Yu, Pang, Yidan, Yu, Haojun, Zhang, Wenqi, Zhao, Xian, Yu, Jianxiu
Format: Article
Language:English
Subjects:
Animals
Consensus Sequence
degradation
DNA-Binding Proteins - chemistry
DNA-Binding Proteins - metabolism
Humans
Multigene Family
Protein Biosynthesis
Review
RNA metabolism
RNA Splicing
RNA Stability
RNA, Messenger - genetics
RNA, Messenger - metabolism
splicing
transcription
Transcription, Genetic
translation
Zinc finger CCHC-type superfamily proteins
Zinc Fingers
zinc-knuckle
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Summary:The zinc finger CCHC-type (ZCCHC) superfamily proteins, characterized with the consensus sequence C-X 2 -C-X 4 -H-X 4 -C, are accepted to have high-affinity binding to single-stranded nucleic acids, especially single-stranded RNAs. In human beings 25 ZCCHC proteins have been annotated in the HGNC database. Of interest is that among the family, most members are involved in the multiple steps of RNA metabolism. In this review, we focus on the diverged roles of human ZCCHC proteins on RNA transcription, biogenesis, splicing, as well as translation and degradation.
ISSN:1547-6286
1555-8584
DOI:10.1080/15476286.2021.1909320