Classics never get old: neurotransmitters shape human cortical interneuron migration

While key developmental functions of neurotransmitters have been described in rodent neural progenitors, there is a lack of understanding of their roles in the human fetal brain. A new study published in The EMBO Journal demonstrates that human cortical interneurons that are moving in fused brain or...

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Bibliographic Details
Published in:The EMBO journal 2021-12, Vol.40 (23), p.e109935-n/a
Main Authors: Bonafina, Antonela, Javier‐Torrent, Míriam, Nguyen, Laurent
Format: Article
Language:English
Subjects:
Biochemistry, biophysics & molecular biology
Biochemistry, Genetics and Molecular Biology (all)
Biochimie, biophysique & biologie moléculaire
Brain
Cell Movement
EMBO27
Fetuses
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology
General Neuroscience
Humans
Immunology and Microbiology (all)
Interneurons
Life sciences
Molecular Biology
Neural stem cells
Neurogenesis
Neuroscience (all)
Neurotransmitter Agents
Neurotransmitter receptors
Neurotransmitters
News & Views
Organoids
Sciences du vivant
Views
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Summary:While key developmental functions of neurotransmitters have been described in rodent neural progenitors, there is a lack of understanding of their roles in the human fetal brain. A new study published in The EMBO Journal demonstrates that human cortical interneurons that are moving in fused brain organoids express a large repertoire of neurotransmitter receptors whose activation fine tunes selective migration strategies. Graphical Abstract Human cortical interneurons express a large repertoire of neurotransmitter receptors whose activation fine tunes selective migration strategies.
ISSN:0261-4189
1460-2075
1460-2075
DOI:10.15252/embj.2021109935