Discrepancies of SARS-CoV-2 testing results among patients with total laryngectomy

Purpose Prevention of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is obtained with nasopharyngeal swabs. By the way, there is no consensus regarding sampling in totally laryngectomized subjects (who thus breathe directly by the tracheostomy and, theoretically, may be infec...

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Bibliographic Details
Published in:European archives of oto-rhino-laryngology 2022-04, Vol.279 (4), p.2193-2196
Main Authors: Fabbris, C., Boaria, F., Boscolo-Rizzo, P., Emanuelli, E., Spinato, G.
Format: Article
Language:English
Subjects:
COVID-19 - diagnosis
COVID-19 Testing
Head and Neck Surgery
Humans
Laryngectomy
Medicine
Medicine & Public Health
Nasopharynx
Neurosurgery
Otorhinolaryngology
Retrospective Studies
SARS-CoV-2
Short Communication
Specimen Handling - methods
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Summary:Purpose Prevention of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is obtained with nasopharyngeal swabs. By the way, there is no consensus regarding sampling in totally laryngectomized subjects (who thus breathe directly by the tracheostomy and, theoretically, may be infected in the trachea). The aim of this study is to evaluate possible differences between swab results in the trachea and in the nasopharynx of this category of patients. Methods A retrospective chart review was performed in April 2021 among patients who previously had been operated on for total laryngectomy and who underwent swabs for SARS-CoV-2 research in 3 health-care centers in Northern–Eastern Italy. Data regarding the site of swabbing (trachea or nasopharynx) were analyzed. A comprehensive review of the literature regarding the same topic was then performed. Results A total of 25 totally laryngectomized subjects underwent swabs. Among them, 5 tested positive in the trachea (1) and in the nasopharynx (4). According to the literature review, 4 more subjects tested positive in the trachea (1) and in the nasopharynx (3). Data were overall divergent and no statistically significant correlations emerged between results of the tests performed in the two sites. Conclusion Due to these discrepancies, both tracheal and nasopharyngeal swabs are recommended in these kinds of patients, to obtain a reliable test and to avoid false negatives.
ISSN:0937-4477
1434-4726
DOI:10.1007/s00405-021-07203-8