Cutaneous papilloma and multicentric squamous cell carcinoma in four-toed hedgehogs (Atelerix albiventris)

Skin lesions possibly caused by Papillomavirus infections in two four-toed hedgehogs are described. In case 1, there was a papillary mass on the right hind limb. Histologically, the mass was consistent with a viral papilloma. In the other case, multifocal papillary masses with erosions and ulcers we...

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Bibliographic Details
Published in:Journal of Veterinary Medical Science 2021, Vol.83(11), pp.1726-1729
Main Authors: OKUMURA, Naka, KOIZUMI, Iori, IWATA, Yuki, YONEYA, Shion, KOBA, Ryota, KONDO, Hirotaka, SHIBUYA, Hisashi
Format: Article
Language:English
Subjects:
four-toed hedgehog
histopathology
neoplasm
papillomavirus
Pathology
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Summary:Skin lesions possibly caused by Papillomavirus infections in two four-toed hedgehogs are described. In case 1, there was a papillary mass on the right hind limb. Histologically, the mass was consistent with a viral papilloma. In the other case, multifocal papillary masses with erosions and ulcers were found throughout the body, mainly on the extremities. Histology showed continuative lesions composed of acanthosis, Bowenoid in situ carcinoma, and squamous cell carcinoma, with abrupt transitions between the lesions. In both cases, keratinocytes in the granular layer infrequently had features of koilocytes and intranuclear inclusion bodies, and immunohistochemical staining was positive for anti-human papillomavirus antibody. To the best of the authors’ knowledge, this is the first pathological documentation of possibly papillomavirus-associated skin lesions in four-toed hedgehogs.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.21-0302