Glucose intolerance and colorectal cancer risk in a nested case-control study among Japanese People

Glucose intolerance may increase the risk of developing colorectal cancer. In a sero-epidemiological nested case-control study, conducted as part of the Japan Collaborative Cohort Study (JACC Study) for Evaluation of Cancer Risk, we measured serum glycoalbumin in 123 patients with colorectal cancer...

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Bibliographic Details
Published in:Journal of epidemiology 2005, Vol.15 Suppl 2 (Supplement_II), p.S180-S184
Main Authors: Ozasa, Kotaro, Ito, Yoshinori, Suzuki, Koji, Watanabe, Yoshiyuki, Kojima, Masayo, Suzuki, Sadao, Tokudome, Shinkan, Tamakoshi, Koji, Toyoshima, Hideaki, Kawado, Miyuki, Hashimoto, Shuji, Hayakawa, Norihiko, Wakai, Kenji, Tamakoshi, Akiko
Format: Article
Language:English
Subjects:
Adult
Aged
Case-Control Studies
Cohort Studies
Colorectal Neoplasms - epidemiology
Colorectal Neoplasms - etiology
Female
Glucose Intolerance - complications
Glucose Intolerance - epidemiology
Glycation End Products, Advanced
Humans
Japan - epidemiology
Male
Middle Aged
Original
Risk Assessment
Risk Factors
Seroepidemiologic Studies
Serum Albumin - analysis
Sex Factors
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Summary:Glucose intolerance may increase the risk of developing colorectal cancer. In a sero-epidemiological nested case-control study, conducted as part of the Japan Collaborative Cohort Study (JACC Study) for Evaluation of Cancer Risk, we measured serum glycoalbumin in 123 patients with colorectal cancer and 279 controls. Conditional logistic regression was used to evaluate the risk of colorectal cancer. There were trends towards an association between high levels of glycoalbumin and an increased risk of colorectal cancer in men (odds ratio [OR]=2.39; 95% confidence interval [CI]; 0.89- 6.36) and between high levels of glycoalbumin and a decreased risk of colorectal cancer in women (OR=0.41; 95% CI, 0.14-1.04). A high level of glycoalbumin may increase the risk of colorectal cancer in men. The finding that high levels of glycoalbumin in women decreased their risk of colorectal cancer was inconsistent with previous reports, and may have been the result of limitations in the procedure in selecting samples and statistical power.
ISSN:0917-5040
1349-9092
DOI:10.2188/jea.15.s180