Renal Prognosis in Children With Tubulointerstitial Nephritis and Uveitis Syndrome

• Published in: Kidney international reports 2021-12, Vol.6 (12), p.3045-3053
• Main Authors: Chevalier, Agnès, Duflos, Claire, Clave, Stephanie, Boyer, Olivia, Hogan, Julien, Lahoche, Annie, Decramer, Stephane, Broux, Françoise, Vrillon, Isabelle, Allain-Launay, Emma, Bacchetta, Justine, Tanne, Corentin, Allard, Lise, Cloarec, Sylvie, Pietrement, Christine, Bourdat-Michel, Guylhene, Djeddi, Djamal, Dunand, Olivier, Faudeux, Camille, Nobili, François, Taque, Sophie, Ulinski, Tim, Zaloszyc, Ariane, Morin, Denis, Fila, Marc
• Format: Article
• Language: English
• Subjects: chronic kidney failure; Clinical Research; Dobrin’s syndrome; Human health and pathology; Life Sciences; outcome; pediatric; Pediatrics; tubulointerstitial nephritis and uveitis syndrome; Urology and Nephrology
• ISSN: 2468-0249; 2468-0249
• DOI: 10.1016/j.ekir.2021.09.017

Tubulointerstitial nephritis (TIN) and uveitis (TINU) syndrome is a rare disease. The renal prognosis is generally thought to be better in children with TINU syndrome than in adults. However, data are scarce. We aimed to investigate the long-term renal prognosis in a French cohort of children with TINU syndrome. We performed a national retrospective study including 23 French pediatric nephrology centers enrolling patients with TINU syndrome diagnosed between January 2000 and December 2018. A total of 46 patients were included (52% female, median age 13.8 years). At diagnosis of TIN, the median estimated glomerular filtration rate (eGFR) was 30.6 ml/min per 1.73 m2 (4.9–62.8). The median time between diagnosis of uveitis and TIN was 0.4 months (−4.1; +17.1). All patients had anterior uveitis, but 12 (29%) were asymptomatic. Nearly all patients (44 of 46) received steroid treatment, and 12 patients (26%) received a second-line therapy. At last follow-up (median 2.8 years), the median eGFR was 87.5 ml/min per 1.73 m2 (60.3–152.7) and