The role of GPR56/ADGRG1 in health and disease

GPR56/ADGRG1 is a versatile adhesion G protein-coupled receptor important in the physiological functions of the central and peripheral nervous systems, reproductive system, muscle hypertrophy, immune regulation, and hematopoietic stem cell generation. By contrast, aberrant expression or deregulated...

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Bibliographic Details
Published in:Biomedical Journal 2021-10, Vol.44 (5), p.534-547
Main Authors: Singh, Abhishek Kumar, Lin, Hsi-Hsien
Format: Article
Language:English
Subjects:
Adhesion GPCR
Cell Transformation, Neoplastic
Depression
G protein
Humans
Ligand
Malformations of Cortical Development
Receptors, G-Protein-Coupled - physiology
Review
Signaling
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Summary:GPR56/ADGRG1 is a versatile adhesion G protein-coupled receptor important in the physiological functions of the central and peripheral nervous systems, reproductive system, muscle hypertrophy, immune regulation, and hematopoietic stem cell generation. By contrast, aberrant expression or deregulated functions of GPR56 have been implicated in diverse pathological processes, including bilateral frontoparietal polymicrogyria, depression, and tumorigenesis. In this review article, we summarize and discuss the current understandings of the role of GPR56 in health and disease.
ISSN:2319-4170
2320-2890
DOI:10.1016/j.bj.2021.04.012