Chemiluminescent Microparticle Immunoassay for the Diagnosis of Congenital Chagas Disease: A Prospective Study in Spain

Congenital Chagas disease (CCD) has become a global health problem. Historically, the diagnosis of CCD has been carried out using parasitological methods and traditional serological techniques, however, new serological techniques such as chemiluminescent microparticle immunoassays (CMIA) have been d...

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Bibliographic Details
Published in:The American journal of tropical medicine and hygiene 2021-10, Vol.105 (6), p.1701-1705
Main Authors: Gil-Gallardo, Luis, Simón, Marina, Iborra, Asunción, Carrilero, Bartolomé, Segovia, Manuel
Format: Article
Language:English
Subjects:
Adult
Antibodies, Protozoan - immunology
Chagas disease
Chagas Disease - congenital
Chagas Disease - diagnosis
Chagas Disease - drug therapy
Chagas Disease - immunology
Congenital diseases
Female
Fetal Blood - immunology
Fluorescent Antibody Technique, Indirect
Humans
Immunoassay
Infant
Infant, Newborn
Luminescent Measurements
Male
Nitroimidazoles - therapeutic use
Prospective Studies
Sensitivity and Specificity
Serology
Spain
Trypanocidal Agents - therapeutic use
Young Adult
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Summary:Congenital Chagas disease (CCD) has become a global health problem. Historically, the diagnosis of CCD has been carried out using parasitological methods and traditional serological techniques, however, new serological techniques such as chemiluminescent microparticle immunoassays (CMIA) have been developed in the last few years with many advantages compared with traditional serological tests. A total of 75 children born to 72 Latin American Chagas-infected mothers were consecutively enrolled and studied by CMIA and indirect immunofluorescence (IIF) at 0-2, 6, 9, and 12 months of age. At the end of the follow-up, 74 out of 75 children were considered uninfected and one child was diagnosed with CCD. Our study emphasizes the need to carry out serological follow-up on every newborn from a mother with Chagas disease and shows that CMIA assay is a great diagnostic tool as a single serological test at 9 months of age to rule out CCD or to identify possible transmission.
ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.21-0332