What is the experience of our patients with transient hypoparathyroidism after total thyroidectomy?

• Published in: Surgery 2021-01, Vol.169 (1), p.70-76
• Main Authors: Doubleday, Amanda R., Robbins, Sarah E., Macdonald, Cameron L., Elfenbein, Dawn M., Connor, Nadine P., Sippel, Rebecca S.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Calcium - blood; Female; Follow-Up Studies; Humans; Hypocalcemia - diagnosis; Hypocalcemia - epidemiology; Hypocalcemia - etiology; Hypocalcemia - psychology; Hypoparathyroidism - diagnosis; Hypoparathyroidism - epidemiology; Hypoparathyroidism - etiology; Hypoparathyroidism - psychology; Male; Middle Aged; Parathyroid Glands - injuries; Parathyroid Glands - metabolism; Parathyroid Hormone - blood; Parathyroid Hormone - metabolism; Postoperative Complications - diagnosis; Postoperative Complications - epidemiology; Postoperative Complications - etiology; Postoperative Complications - psychology; Preoperative Period; Prospective Studies; Qualitative Research; Quality of Life; Risk Factors; Thyroid Neoplasms - blood; Thyroid Neoplasms - surgery; Thyroidectomy - adverse effects; Young Adult
• ISSN: 0039-6060; 1532-7361
• DOI: 10.1016/j.surg.2020.04.029

We sought to better understand the experience of patients with transient hypoparathyroidism using patient interviews and quality of life surveys. This is a prospective analysis of 62 patients after total thyroidectomy at a high-volume institution. Semistructured patient interviews and quality of life surveys were conducted preoperatively and postoperatively at 2 weeks, 6 weeks, 6 months, and 1 year and compared based on postoperative parathyroid hormone levels. Postoperative parathyroid hormone levels were 20 pg/mL in 48% (n = 30). Hypocalcemic symptoms at 2 weeks were reported in 28 of 55 patients (51%), but patients felt “well prepared” and reported it “wasn’t a big deal.” If symptoms persisted at 6 weeks, they became more bothersome. At 6 months and 1 year, patients reported calcium supplementation prevented most symptoms and did not interfere with daily activities. Quality of life as measured by the European Organization for Research and Treatment of Cancer and the 12-Item Short Form Survey demonstrated a slight improvement at 1 year postoperatively regardless of parathyroid hormone level. Early postoperative transient hypoparathyroidism is common but when appropriately managed did not have a substantial negative impact on the overall quality of life.