Asthma as a risk factor for hospitalization in children with COVID‐19: A nested case‐control study

Background Most pediatric studies of asthma and COVID‐19 to date have been ecological, which offer limited insight. We evaluated the association between asthma and COVID‐19 at an individual level. Methods Using data from prospective clinical registries, we conducted a nested case‐control study compa...

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Published in:Pediatric allergy and immunology 2022-01, Vol.33 (1), p.e13696-n/a
Main Authors: Gaietto, Kristina, Freeman, Megan Culler, DiCicco, Leigh Anne, Rauenswinter, Sherry, Squire, Joseph R., Aldewereld, Zachary, Iagnemma, Jennifer, Campfield, Brian T., Wolfson, David, Kazmerski, Traci M., Forno, Erick, Kalayci, Ömer
Format: Article
Language:English
Subjects:
Asthma
Asthma - drug therapy
Asthma - epidemiology
Case-Control Studies
Child
Children
COVID-19
Dyspnea
Hospitalization
Humans
Original
Pediatrics
Prospective Studies
Respiration
Risk Factors
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Steroid hormones
Wheezing
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Summary:Background Most pediatric studies of asthma and COVID‐19 to date have been ecological, which offer limited insight. We evaluated the association between asthma and COVID‐19 at an individual level. Methods Using data from prospective clinical registries, we conducted a nested case‐control study comparing three groups: children with COVID‐19 and underlying asthma (“A+C” cases); children with COVID‐19 without underlying disease (“C+” controls); and children with asthma without COVID‐19 (“A+” controls). Results The cohort included 142 A+C cases, 1110 C+ controls, and 140 A+ controls. A+C cases were more likely than C+ controls to present with dyspnea and wheezing, to receive pharmacologic treatment including systemic steroids (all p 
ISSN:0905-6157
1399-3038
DOI:10.1111/pai.13696