Potential role of embelin in the prevention of Freund’s adjuvant induced inflammation and ROS

• Published in: 3 Biotech 2022-01, Vol.12 (1), p.10-10, Article 10
• Main Authors: Kumaraswamy, H. M., Krishna, V., Sharath, R., Satyanarayan, N. D., Meghana, P., Jain, R. Sandeep Kumar, Prashanth, N., Raja Naika, H.
• Format: Article
• Language: English
• Subjects: Agriculture; Anti-inflammatory agents; Antioxidants; Benzoquinone; Bioinformatics; Biomaterials; Biotechnology; Cancer Research; Carrageenan; Carrageenans; Chemistry; Chemistry and Materials Science; Cyclooxygenase-2; Edema; Embelia; Hydrogen bonding; Hydrogen bonds; Immune system; Inflammation; Original; Original Article; Oxidative stress; Spleen; Stem Cells
• ISSN: 2190-572X; 2190-5738
• DOI: 10.1007/s13205-021-03071-5

Inflammation is a complex biological response involving immune cells to an infection creating injury to the normal tissues. The anti-inflammatory efficacy of embelin, a benzoquinone from the plant Embelia ribes , was screened for antioxidant and anti-inflammatory activity in carrageenan and Freund’s adjuvant-induced inflammation models. Embelin exhibited significant dose-dependent antioxidant potential. In carrageenan-induced inflammation, embelin (20 mg/kg) showed an inhibition of oedema by 71.01 ± 0.12% and 81.91 ± 0.67% in Freund’s adjuvant-treated chronic inflammation model and resulted in a noticeable increase in adrenal size and restoration of the weight of spleen. Embelin also demonstrated cytoprotective effects on HEK-293 cells under induced oxidative stress. In silico analysis, embelin demonstrated binding energy of − 7.7 kcal/Mol and − 7.0 kcal/Mol with COX1 and COX2 with two hydrogen bonds. These results further prove that embelin could be a promising anti-inflammatory agent and supports the traditional use of Embelia ribes for rheumatism.