The Role of Innate Immune Cells in Tumor Invasion and Metastasis

Metastasis is considered one of the hallmarks of cancer and enhanced tumor invasion and metastasis is significantly associated with cancer mortality. Metastasis occurs via a series of integrated processes involving tumor cells and the tumor microenvironment. The innate immune components of the micro...

Full description

Saved in:
Bibliographic Details
Published in:Cancers 2021-11, Vol.13 (23), p.5885
Main Authors: Huang, Yu-Kuan, Busuttil, Rita A, Boussioutas, Alex
Format: Article
Language:English
Subjects:
Antigen presentation
Cancer
Cell proliferation
Chemokines
Cytokines
Dendritic cells
Genotype & phenotype
Granulocytes
Growth factors
Hypoxia
Immune system
Inflammation
Innate immunity
Ligands
Lymphocytes
Metastases
Metastasis
Motility
Neutrophils
Nitric oxide
Review
Transcription factors
Tumor cells
Tumor microenvironment
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Metastasis is considered one of the hallmarks of cancer and enhanced tumor invasion and metastasis is significantly associated with cancer mortality. Metastasis occurs via a series of integrated processes involving tumor cells and the tumor microenvironment. The innate immune components of the microenvironment have been shown to engage with tumor cells and not only regulate their proliferation and survival, but also modulate the surrounding environment to enable cancer progression. In the era of immune therapies, it is critical to understand how different innate immune cell populations are involved in this process. This review summarizes recent literature describing the roles of innate immune cells during the tumor metastatic cascade.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers13235885