Epigenetic Dysregulation of KCNK9 Imprinting and Triple-Negative Breast Cancer

Genomic imprinting is an inherited form of parent-of-origin specific epigenetic gene regulation that is dysregulated by poor prenatal nutrition and environmental toxins. encodes for TASK3, a pH-regulated potassium channel membrane protein that is overexpressed in 40% of breast cancer. However, gene...

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Bibliographic Details
Published in:Cancers 2021-11, Vol.13 (23), p.6031
Main Authors: Skaar, David A, Dietze, Eric C, Alva-Ornelas, Jackelyn A, Ann, David, Schones, Dustin E, Hyslop, Terry, Sistrunk, Christopher, Zalles, Carola, Ambrose, Adrian, Kennedy, Kendall, Idassi, Ombeni, Miranda Carboni, Gustavo, Gould, Michael N, Jirtle, Randy L, Seewaldt, Victoria L
Format: Article
Language:English
Subjects:
Apoptosis
Biotechnology
Brain
Breast cancer
Cell growth
Cellular biology
Cloning
DNA methylation
Epigenetics
Epithelial cells
Gene amplification
Gene expression
Gene regulation
Genomic imprinting
Human subjects
Mammary gland
Membrane potential
Membrane proteins
Mitochondria
Mutagenesis
Potassium
Potassium channels
Proteins
Womens health
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Summary:Genomic imprinting is an inherited form of parent-of-origin specific epigenetic gene regulation that is dysregulated by poor prenatal nutrition and environmental toxins. encodes for TASK3, a pH-regulated potassium channel membrane protein that is overexpressed in 40% of breast cancer. However, gene amplification accounts for increased expression in
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers13236031