The Role and Significance of Bioumoral Markers in Prostate Cancer

The prostate is one of the most clinically accessible internal organs of the genitourinary tract in men. For decades, the only method of screening for prostate cancer (PCa) has been digital rectal examination of 1990s significantly increased the incidence and prevalence of PCa and consequently the m...

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Bibliographic Details
Published in:Cancers 2021-11, Vol.13 (23), p.5932
Main Authors: Constantin, Traian, Savu, Diana Alexandra, Bucur, Ștefana, Predoiu, Gabriel, Constantin, Maria Magdalena, Jinga, Viorel
Format: Article
Language:English
Subjects:
Biomarkers
Biopsy
Breast cancer
Genitourinary tract
Metastases
Morbidity
Mortality
Patients
Prostate cancer
Quality of life
Review
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Summary:The prostate is one of the most clinically accessible internal organs of the genitourinary tract in men. For decades, the only method of screening for prostate cancer (PCa) has been digital rectal examination of 1990s significantly increased the incidence and prevalence of PCa and consequently the morbidity and mortality associated with this disease. In addition, the different types of oncology treatment methods have been linked to specific complications and side effects, which would affect the patient's quality of life. In the first two decades of the 21st century, over-detection and over-treatment of PCa patients has generated enormous costs for health systems, especially in Europe and the United States. The Prostate Specific Antigen (PSA) is still the most common and accessible screening blood test for PCa, but with low sensibility and specificity at lower values (
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers13235932