The Effect of Letrozole Combined with Dydrogesterone for Endometriosis in China: A Meta-Analysis

Purpose. To discuss the effects of dydrogesterone combined with letrozole on the effectiveness, sex hormone levels, and serological indicators in patients with endometriosis. This study is registered with PROSPERO (CRD42020213172). Methods. We searched relevant randomized controlled trials (RCTs) th...

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Bibliographic Details
Published in:BioMed research international 2021, Vol.2021, p.9946060-10
Main Authors: Sun, Shumei, Zhang, Hao, Zhong, Peicheng, Xu, Zhihong
Format: Article
Language:English
Subjects:
Analysis
Animals
Antigens
Bias
Carbohydrates
Care and treatment
China
Clinical trials
Confidence intervals
Cytokines
Diagnosis
Dydrogesterone - therapeutic use
Endometriosis
Endometriosis - drug therapy
Endometriosis - metabolism
Estrogens
Female
Follicle-stimulating hormone
Growth factors
Health aspects
Humans
Indicators
Infertility
Interleukin 6
Letrozole - therapeutic use
Luteinizing hormone
Measurement
Meta-analysis
Pain
Progesterone
Randomized Controlled Trials as Topic
Review
Risk factors
Sex hormones
Source studies
Tumor Necrosis Factor-alpha - metabolism
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A - metabolism
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Summary:Purpose. To discuss the effects of dydrogesterone combined with letrozole on the effectiveness, sex hormone levels, and serological indicators in patients with endometriosis. This study is registered with PROSPERO (CRD42020213172). Methods. We searched relevant randomized controlled trials (RCTs) through PubMed, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang, and VIP Database. The standardized mean differences (SMDs), the mean differences (MDs), or odds ratios (ORs) with their 95% confidence intervals (95% CIs) were computed to be outcome indicators, including total effectiveness, Vascular Endothelial Growth Factor (VEGF) level, Carbohydrate Antigen 125 (CA125) level, Follicle-Stimulating Hormone (FSH) level, Luteinizing Hormone (LH) level, estrogen (E2) level, progesterone (P) level, interleukin-6 (IL-6) level, and tumor necrosis factor-a (TNF-a) level. Results. A total of 19 RCTs involving 1,591 patients were included in this study. Our results showed that letrozole combined with dydrogesterone can significantly reduce the levels of VEGF (SMD -2.23, 95% CI -2.39 to -2.07; p
ISSN:2314-6133
2314-6141
DOI:10.1155/2021/9946060