Expression of miR-210, miR-137, and miR-153 in Patients with Acute Cerebral Infarction

Aim. To explore the expression levels of miR-210, miR-137, and miR-153 in patients with acute cerebral infarction. Material and Methods. 76 patients with acute cerebral infarction treated in our hospital from April 2016 to October 2017 were enrolled as the observation group. Another 64 normal patien...

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Bibliographic Details
Published in:BioMed research international 2021, Vol.2021 (1), p.4464945-4464945
Main Authors: Tian, Hongtao, Zhao, Yan, Du, Chao, Zong, Xiao, Zhang, Xiuping, Qiao, Xia
Format: Article
Language:English
Subjects:
Acute Disease - mortality
Analysis
Brain Ischemia - genetics
Brain Ischemia - mortality
Brain Ischemia - pathology
Brain-derived neurotrophic factor
Care and treatment
Casualties
Cerebral infarction
Cerebral Infarction - genetics
Cerebral Infarction - mortality
Cerebral Infarction - pathology
Correlation analysis
Death
Diabetes
Diagnosis
Diagnostic systems
Female
Hospital patients
Humans
Hypertension
Infarction
Male
Males
Medical prognosis
Medical research
MicroRNA
MicroRNAs
MicroRNAs - genetics
Middle Aged
Mortality
Patients
Prognosis
Risk factors
ROC Curve
Schizophrenia
Software
Statistical analysis
Stroke
Stroke (Disease)
Stroke - genetics
Stroke - pathology
Survival
Survival analysis
Survival Rate
Traumatic brain injury
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Summary:Aim. To explore the expression levels of miR-210, miR-137, and miR-153 in patients with acute cerebral infarction. Material and Methods. 76 patients with acute cerebral infarction treated in our hospital from April 2016 to October 2017 were enrolled as the observation group. Another 64 normal patients were selected as the control group. The patients were divided into the death and survival groups based on 1-year mortality of patients. qRT-PCR was used to detect the expression of miR-210, miR-137, and miR-153 in the serum of each group. Receiver operating characteristic (ROC) curve was employed to analyze the diagnostic value and predictive value of miR-210, miR-137 and miR-153 death in patients. The correlation between miR-210, miR-137, and miR-153 in the serum of the observation group was analyzed by Pearson’s test. Results. Levels of miR-210 and miR-137 in the observation group were significantly lower than those in the control group, while levels of miR-153 in the observation group were significantly higher than those in the control group (all P
ISSN:2314-6133
2314-6141
DOI:10.1155/2021/4464945