Loading…
Expression of miR-210, miR-137, and miR-153 in Patients with Acute Cerebral Infarction
Aim. To explore the expression levels of miR-210, miR-137, and miR-153 in patients with acute cerebral infarction. Material and Methods. 76 patients with acute cerebral infarction treated in our hospital from April 2016 to October 2017 were enrolled as the observation group. Another 64 normal patien...
Saved in:
Published in: | BioMed research international 2021, Vol.2021 (1), p.4464945-4464945 |
---|---|
Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c476t-9612efa6e4fafba2c566ec4a5796d890ae168d18f004ab46af3a72b176f4eae53 |
---|---|
cites | cdi_FETCH-LOGICAL-c476t-9612efa6e4fafba2c566ec4a5796d890ae168d18f004ab46af3a72b176f4eae53 |
container_end_page | 4464945 |
container_issue | 1 |
container_start_page | 4464945 |
container_title | BioMed research international |
container_volume | 2021 |
creator | Tian, Hongtao Zhao, Yan Du, Chao Zong, Xiao Zhang, Xiuping Qiao, Xia |
description | Aim. To explore the expression levels of miR-210, miR-137, and miR-153 in patients with acute cerebral infarction. Material and Methods. 76 patients with acute cerebral infarction treated in our hospital from April 2016 to October 2017 were enrolled as the observation group. Another 64 normal patients were selected as the control group. The patients were divided into the death and survival groups based on 1-year mortality of patients. qRT-PCR was used to detect the expression of miR-210, miR-137, and miR-153 in the serum of each group. Receiver operating characteristic (ROC) curve was employed to analyze the diagnostic value and predictive value of miR-210, miR-137 and miR-153 death in patients. The correlation between miR-210, miR-137, and miR-153 in the serum of the observation group was analyzed by Pearson’s test. Results. Levels of miR-210 and miR-137 in the observation group were significantly lower than those in the control group, while levels of miR-153 in the observation group were significantly higher than those in the control group (all P |
doi_str_mv | 10.1155/2021/4464945 |
format | article |
fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8660189</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A696967007</galeid><sourcerecordid>A696967007</sourcerecordid><originalsourceid>FETCH-LOGICAL-c476t-9612efa6e4fafba2c566ec4a5796d890ae168d18f004ab46af3a72b176f4eae53</originalsourceid><addsrcrecordid>eNp9kcFvFCEUh4nR2Kb25tmQeDFxx_IYhhkuJptN1SZNNEa9kjcMdGlmYYWZVv97WXfdVA_CgUf48vHgR8hzYG8AmuaCMw4XQkihRPOInPIaRCVBwONjXdcn5DznW1ZGB5Ip-ZSc1EIx4C0_Jd8uf2yTzdnHQKOjG_-54sAWvwuo2wXFMOw3TU19oJ9w8jZMmd77aU2XZp4sXdlk-4QjvQoOk5mK6xl54nDM9vywnpGv7y6_rD5U1x_fX62W15URrZwqJYFbh9IKh65HbhoprRHYtEoOnWJoQXYDdI4xgb2Q6GpseQ-tdMKibeoz8nbv3c79xg6mtFYa0dvkN5h-6ohe_30S_FrfxDvdScmgU0Xw6iBI8fts86Q3Phs7jhhsnLPmEhhrOy54QV_-g97GOYXyvEIxBU358QfUDY5W--BiudfspHopVZlt8RVqsadMijkn644tA9O7ZPUuWX1ItuAvHj7zCP_JsQCv98DahwHv_f91vwA1eKcB</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2609152312</pqid></control><display><type>article</type><title>Expression of miR-210, miR-137, and miR-153 in Patients with Acute Cerebral Infarction</title><source>Wiley-Blackwell Open Access Collection</source><source>Publicly Available Content (ProQuest)</source><creator>Tian, Hongtao ; Zhao, Yan ; Du, Chao ; Zong, Xiao ; Zhang, Xiuping ; Qiao, Xia</creator><contributor>Yang, Jun ; Jun Yang</contributor><creatorcontrib>Tian, Hongtao ; Zhao, Yan ; Du, Chao ; Zong, Xiao ; Zhang, Xiuping ; Qiao, Xia ; Yang, Jun ; Jun Yang</creatorcontrib><description>Aim. To explore the expression levels of miR-210, miR-137, and miR-153 in patients with acute cerebral infarction. Material and Methods. 76 patients with acute cerebral infarction treated in our hospital from April 2016 to October 2017 were enrolled as the observation group. Another 64 normal patients were selected as the control group. The patients were divided into the death and survival groups based on 1-year mortality of patients. qRT-PCR was used to detect the expression of miR-210, miR-137, and miR-153 in the serum of each group. Receiver operating characteristic (ROC) curve was employed to analyze the diagnostic value and predictive value of miR-210, miR-137 and miR-153 death in patients. The correlation between miR-210, miR-137, and miR-153 in the serum of the observation group was analyzed by Pearson’s test. Results. Levels of miR-210 and miR-137 in the observation group were significantly lower than those in the control group, while levels of miR-153 in the observation group were significantly higher than those in the control group (all P<0.05). The ROC curve of diagnosis of acute cerebral infarction showed that the area under curve of miR-210 was 0.836, that of miR-137 was 0.843, and that of miR-153 was 0.842. The 1-year survival rate was 71.05%. The 1-year survival of the low-expression group of miR-210 and miR-137 was significantly lower than that of the high-expression group, while the 1-year survival of the low-expression group of miR-153 was significantly higher than that of the high-expression group (all P<0.05). The ROC curve for predicting death showed that the area under curve of miR-210 was 0.786, that of miR-137 was 0.824, and that of miR-153 was 0.858. Pearson’s correlation analysis showed that the expression of miR-210 was positively correlated with that of miR-137, while miR-137 was negatively correlated with that of miR-153 and miR-210 was negatively correlated with that of miR-153. Conclusion. miR-210, miR-137, and miR-153 have a certain value in the diagnosis and prediction of 1-year death of acute cerebral infarction and may be potential diagnostic and predictive indicators.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2021/4464945</identifier><identifier>PMID: 34901272</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Acute Disease - mortality ; Analysis ; Brain Ischemia - genetics ; Brain Ischemia - mortality ; Brain Ischemia - pathology ; Brain-derived neurotrophic factor ; Care and treatment ; Casualties ; Cerebral infarction ; Cerebral Infarction - genetics ; Cerebral Infarction - mortality ; Cerebral Infarction - pathology ; Correlation analysis ; Death ; Diabetes ; Diagnosis ; Diagnostic systems ; Female ; Hospital patients ; Humans ; Hypertension ; Infarction ; Male ; Males ; Medical prognosis ; Medical research ; MicroRNA ; MicroRNAs ; MicroRNAs - genetics ; Middle Aged ; Mortality ; Patients ; Prognosis ; Risk factors ; ROC Curve ; Schizophrenia ; Software ; Statistical analysis ; Stroke ; Stroke (Disease) ; Stroke - genetics ; Stroke - pathology ; Survival ; Survival analysis ; Survival Rate ; Traumatic brain injury</subject><ispartof>BioMed research international, 2021, Vol.2021 (1), p.4464945-4464945</ispartof><rights>Copyright © 2021 Hongtao Tian et al.</rights><rights>COPYRIGHT 2021 John Wiley & Sons, Inc.</rights><rights>Copyright © 2021 Hongtao Tian et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 Hongtao Tian et al. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-9612efa6e4fafba2c566ec4a5796d890ae168d18f004ab46af3a72b176f4eae53</citedby><cites>FETCH-LOGICAL-c476t-9612efa6e4fafba2c566ec4a5796d890ae168d18f004ab46af3a72b176f4eae53</cites><orcidid>0000-0002-5652-6402</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2609152312/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2609152312?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,4024,25753,27923,27924,27925,37012,37013,44590,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34901272$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Yang, Jun</contributor><contributor>Jun Yang</contributor><creatorcontrib>Tian, Hongtao</creatorcontrib><creatorcontrib>Zhao, Yan</creatorcontrib><creatorcontrib>Du, Chao</creatorcontrib><creatorcontrib>Zong, Xiao</creatorcontrib><creatorcontrib>Zhang, Xiuping</creatorcontrib><creatorcontrib>Qiao, Xia</creatorcontrib><title>Expression of miR-210, miR-137, and miR-153 in Patients with Acute Cerebral Infarction</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Aim. To explore the expression levels of miR-210, miR-137, and miR-153 in patients with acute cerebral infarction. Material and Methods. 76 patients with acute cerebral infarction treated in our hospital from April 2016 to October 2017 were enrolled as the observation group. Another 64 normal patients were selected as the control group. The patients were divided into the death and survival groups based on 1-year mortality of patients. qRT-PCR was used to detect the expression of miR-210, miR-137, and miR-153 in the serum of each group. Receiver operating characteristic (ROC) curve was employed to analyze the diagnostic value and predictive value of miR-210, miR-137 and miR-153 death in patients. The correlation between miR-210, miR-137, and miR-153 in the serum of the observation group was analyzed by Pearson’s test. Results. Levels of miR-210 and miR-137 in the observation group were significantly lower than those in the control group, while levels of miR-153 in the observation group were significantly higher than those in the control group (all P<0.05). The ROC curve of diagnosis of acute cerebral infarction showed that the area under curve of miR-210 was 0.836, that of miR-137 was 0.843, and that of miR-153 was 0.842. The 1-year survival rate was 71.05%. The 1-year survival of the low-expression group of miR-210 and miR-137 was significantly lower than that of the high-expression group, while the 1-year survival of the low-expression group of miR-153 was significantly higher than that of the high-expression group (all P<0.05). The ROC curve for predicting death showed that the area under curve of miR-210 was 0.786, that of miR-137 was 0.824, and that of miR-153 was 0.858. Pearson’s correlation analysis showed that the expression of miR-210 was positively correlated with that of miR-137, while miR-137 was negatively correlated with that of miR-153 and miR-210 was negatively correlated with that of miR-153. Conclusion. miR-210, miR-137, and miR-153 have a certain value in the diagnosis and prediction of 1-year death of acute cerebral infarction and may be potential diagnostic and predictive indicators.</description><subject>Acute Disease - mortality</subject><subject>Analysis</subject><subject>Brain Ischemia - genetics</subject><subject>Brain Ischemia - mortality</subject><subject>Brain Ischemia - pathology</subject><subject>Brain-derived neurotrophic factor</subject><subject>Care and treatment</subject><subject>Casualties</subject><subject>Cerebral infarction</subject><subject>Cerebral Infarction - genetics</subject><subject>Cerebral Infarction - mortality</subject><subject>Cerebral Infarction - pathology</subject><subject>Correlation analysis</subject><subject>Death</subject><subject>Diabetes</subject><subject>Diagnosis</subject><subject>Diagnostic systems</subject><subject>Female</subject><subject>Hospital patients</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Infarction</subject><subject>Male</subject><subject>Males</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Risk factors</subject><subject>ROC Curve</subject><subject>Schizophrenia</subject><subject>Software</subject><subject>Statistical analysis</subject><subject>Stroke</subject><subject>Stroke (Disease)</subject><subject>Stroke - genetics</subject><subject>Stroke - pathology</subject><subject>Survival</subject><subject>Survival analysis</subject><subject>Survival Rate</subject><subject>Traumatic brain injury</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNp9kcFvFCEUh4nR2Kb25tmQeDFxx_IYhhkuJptN1SZNNEa9kjcMdGlmYYWZVv97WXfdVA_CgUf48vHgR8hzYG8AmuaCMw4XQkihRPOInPIaRCVBwONjXdcn5DznW1ZGB5Ip-ZSc1EIx4C0_Jd8uf2yTzdnHQKOjG_-54sAWvwuo2wXFMOw3TU19oJ9w8jZMmd77aU2XZp4sXdlk-4QjvQoOk5mK6xl54nDM9vywnpGv7y6_rD5U1x_fX62W15URrZwqJYFbh9IKh65HbhoprRHYtEoOnWJoQXYDdI4xgb2Q6GpseQ-tdMKibeoz8nbv3c79xg6mtFYa0dvkN5h-6ohe_30S_FrfxDvdScmgU0Xw6iBI8fts86Q3Phs7jhhsnLPmEhhrOy54QV_-g97GOYXyvEIxBU358QfUDY5W--BiudfspHopVZlt8RVqsadMijkn644tA9O7ZPUuWX1ItuAvHj7zCP_JsQCv98DahwHv_f91vwA1eKcB</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Tian, Hongtao</creator><creator>Zhao, Yan</creator><creator>Du, Chao</creator><creator>Zong, Xiao</creator><creator>Zhang, Xiuping</creator><creator>Qiao, Xia</creator><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5652-6402</orcidid></search><sort><creationdate>2021</creationdate><title>Expression of miR-210, miR-137, and miR-153 in Patients with Acute Cerebral Infarction</title><author>Tian, Hongtao ; Zhao, Yan ; Du, Chao ; Zong, Xiao ; Zhang, Xiuping ; Qiao, Xia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-9612efa6e4fafba2c566ec4a5796d890ae168d18f004ab46af3a72b176f4eae53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acute Disease - mortality</topic><topic>Analysis</topic><topic>Brain Ischemia - genetics</topic><topic>Brain Ischemia - mortality</topic><topic>Brain Ischemia - pathology</topic><topic>Brain-derived neurotrophic factor</topic><topic>Care and treatment</topic><topic>Casualties</topic><topic>Cerebral infarction</topic><topic>Cerebral Infarction - genetics</topic><topic>Cerebral Infarction - mortality</topic><topic>Cerebral Infarction - pathology</topic><topic>Correlation analysis</topic><topic>Death</topic><topic>Diabetes</topic><topic>Diagnosis</topic><topic>Diagnostic systems</topic><topic>Female</topic><topic>Hospital patients</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Infarction</topic><topic>Male</topic><topic>Males</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>MicroRNA</topic><topic>MicroRNAs</topic><topic>MicroRNAs - genetics</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Risk factors</topic><topic>ROC Curve</topic><topic>Schizophrenia</topic><topic>Software</topic><topic>Statistical analysis</topic><topic>Stroke</topic><topic>Stroke (Disease)</topic><topic>Stroke - genetics</topic><topic>Stroke - pathology</topic><topic>Survival</topic><topic>Survival analysis</topic><topic>Survival Rate</topic><topic>Traumatic brain injury</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tian, Hongtao</creatorcontrib><creatorcontrib>Zhao, Yan</creatorcontrib><creatorcontrib>Du, Chao</creatorcontrib><creatorcontrib>Zong, Xiao</creatorcontrib><creatorcontrib>Zhang, Xiuping</creatorcontrib><creatorcontrib>Qiao, Xia</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tian, Hongtao</au><au>Zhao, Yan</au><au>Du, Chao</au><au>Zong, Xiao</au><au>Zhang, Xiuping</au><au>Qiao, Xia</au><au>Yang, Jun</au><au>Jun Yang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of miR-210, miR-137, and miR-153 in Patients with Acute Cerebral Infarction</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2021</date><risdate>2021</risdate><volume>2021</volume><issue>1</issue><spage>4464945</spage><epage>4464945</epage><pages>4464945-4464945</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Aim. To explore the expression levels of miR-210, miR-137, and miR-153 in patients with acute cerebral infarction. Material and Methods. 76 patients with acute cerebral infarction treated in our hospital from April 2016 to October 2017 were enrolled as the observation group. Another 64 normal patients were selected as the control group. The patients were divided into the death and survival groups based on 1-year mortality of patients. qRT-PCR was used to detect the expression of miR-210, miR-137, and miR-153 in the serum of each group. Receiver operating characteristic (ROC) curve was employed to analyze the diagnostic value and predictive value of miR-210, miR-137 and miR-153 death in patients. The correlation between miR-210, miR-137, and miR-153 in the serum of the observation group was analyzed by Pearson’s test. Results. Levels of miR-210 and miR-137 in the observation group were significantly lower than those in the control group, while levels of miR-153 in the observation group were significantly higher than those in the control group (all P<0.05). The ROC curve of diagnosis of acute cerebral infarction showed that the area under curve of miR-210 was 0.836, that of miR-137 was 0.843, and that of miR-153 was 0.842. The 1-year survival rate was 71.05%. The 1-year survival of the low-expression group of miR-210 and miR-137 was significantly lower than that of the high-expression group, while the 1-year survival of the low-expression group of miR-153 was significantly higher than that of the high-expression group (all P<0.05). The ROC curve for predicting death showed that the area under curve of miR-210 was 0.786, that of miR-137 was 0.824, and that of miR-153 was 0.858. Pearson’s correlation analysis showed that the expression of miR-210 was positively correlated with that of miR-137, while miR-137 was negatively correlated with that of miR-153 and miR-210 was negatively correlated with that of miR-153. Conclusion. miR-210, miR-137, and miR-153 have a certain value in the diagnosis and prediction of 1-year death of acute cerebral infarction and may be potential diagnostic and predictive indicators.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>34901272</pmid><doi>10.1155/2021/4464945</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-5652-6402</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 2314-6133 |
ispartof | BioMed research international, 2021, Vol.2021 (1), p.4464945-4464945 |
issn | 2314-6133 2314-6141 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8660189 |
source | Wiley-Blackwell Open Access Collection; Publicly Available Content (ProQuest) |
subjects | Acute Disease - mortality Analysis Brain Ischemia - genetics Brain Ischemia - mortality Brain Ischemia - pathology Brain-derived neurotrophic factor Care and treatment Casualties Cerebral infarction Cerebral Infarction - genetics Cerebral Infarction - mortality Cerebral Infarction - pathology Correlation analysis Death Diabetes Diagnosis Diagnostic systems Female Hospital patients Humans Hypertension Infarction Male Males Medical prognosis Medical research MicroRNA MicroRNAs MicroRNAs - genetics Middle Aged Mortality Patients Prognosis Risk factors ROC Curve Schizophrenia Software Statistical analysis Stroke Stroke (Disease) Stroke - genetics Stroke - pathology Survival Survival analysis Survival Rate Traumatic brain injury |
title | Expression of miR-210, miR-137, and miR-153 in Patients with Acute Cerebral Infarction |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T06%3A27%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Expression%20of%20miR-210,%20miR-137,%20and%20miR-153%20in%20Patients%20with%20Acute%20Cerebral%20Infarction&rft.jtitle=BioMed%20research%20international&rft.au=Tian,%20Hongtao&rft.date=2021&rft.volume=2021&rft.issue=1&rft.spage=4464945&rft.epage=4464945&rft.pages=4464945-4464945&rft.issn=2314-6133&rft.eissn=2314-6141&rft_id=info:doi/10.1155/2021/4464945&rft_dat=%3Cgale_pubme%3EA696967007%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c476t-9612efa6e4fafba2c566ec4a5796d890ae168d18f004ab46af3a72b176f4eae53%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2609152312&rft_id=info:pmid/34901272&rft_galeid=A696967007&rfr_iscdi=true |