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Expression of miR-210, miR-137, and miR-153 in Patients with Acute Cerebral Infarction

Aim. To explore the expression levels of miR-210, miR-137, and miR-153 in patients with acute cerebral infarction. Material and Methods. 76 patients with acute cerebral infarction treated in our hospital from April 2016 to October 2017 were enrolled as the observation group. Another 64 normal patien...

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Published in:BioMed research international 2021, Vol.2021 (1), p.4464945-4464945
Main Authors: Tian, Hongtao, Zhao, Yan, Du, Chao, Zong, Xiao, Zhang, Xiuping, Qiao, Xia
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Zhao, Yan
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Qiao, Xia
description Aim. To explore the expression levels of miR-210, miR-137, and miR-153 in patients with acute cerebral infarction. Material and Methods. 76 patients with acute cerebral infarction treated in our hospital from April 2016 to October 2017 were enrolled as the observation group. Another 64 normal patients were selected as the control group. The patients were divided into the death and survival groups based on 1-year mortality of patients. qRT-PCR was used to detect the expression of miR-210, miR-137, and miR-153 in the serum of each group. Receiver operating characteristic (ROC) curve was employed to analyze the diagnostic value and predictive value of miR-210, miR-137 and miR-153 death in patients. The correlation between miR-210, miR-137, and miR-153 in the serum of the observation group was analyzed by Pearson’s test. Results. Levels of miR-210 and miR-137 in the observation group were significantly lower than those in the control group, while levels of miR-153 in the observation group were significantly higher than those in the control group (all P
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To explore the expression levels of miR-210, miR-137, and miR-153 in patients with acute cerebral infarction. Material and Methods. 76 patients with acute cerebral infarction treated in our hospital from April 2016 to October 2017 were enrolled as the observation group. Another 64 normal patients were selected as the control group. The patients were divided into the death and survival groups based on 1-year mortality of patients. qRT-PCR was used to detect the expression of miR-210, miR-137, and miR-153 in the serum of each group. Receiver operating characteristic (ROC) curve was employed to analyze the diagnostic value and predictive value of miR-210, miR-137 and miR-153 death in patients. The correlation between miR-210, miR-137, and miR-153 in the serum of the observation group was analyzed by Pearson’s test. Results. Levels of miR-210 and miR-137 in the observation group were significantly lower than those in the control group, while levels of miR-153 in the observation group were significantly higher than those in the control group (all P&lt;0.05). The ROC curve of diagnosis of acute cerebral infarction showed that the area under curve of miR-210 was 0.836, that of miR-137 was 0.843, and that of miR-153 was 0.842. The 1-year survival rate was 71.05%. The 1-year survival of the low-expression group of miR-210 and miR-137 was significantly lower than that of the high-expression group, while the 1-year survival of the low-expression group of miR-153 was significantly higher than that of the high-expression group (all P&lt;0.05). The ROC curve for predicting death showed that the area under curve of miR-210 was 0.786, that of miR-137 was 0.824, and that of miR-153 was 0.858. Pearson’s correlation analysis showed that the expression of miR-210 was positively correlated with that of miR-137, while miR-137 was negatively correlated with that of miR-153 and miR-210 was negatively correlated with that of miR-153. Conclusion. miR-210, miR-137, and miR-153 have a certain value in the diagnosis and prediction of 1-year death of acute cerebral infarction and may be potential diagnostic and predictive indicators.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2021/4464945</identifier><identifier>PMID: 34901272</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Acute Disease - mortality ; Analysis ; Brain Ischemia - genetics ; Brain Ischemia - mortality ; Brain Ischemia - pathology ; Brain-derived neurotrophic factor ; Care and treatment ; Casualties ; Cerebral infarction ; Cerebral Infarction - genetics ; Cerebral Infarction - mortality ; Cerebral Infarction - pathology ; Correlation analysis ; Death ; Diabetes ; Diagnosis ; Diagnostic systems ; Female ; Hospital patients ; Humans ; Hypertension ; Infarction ; Male ; Males ; Medical prognosis ; Medical research ; MicroRNA ; MicroRNAs ; MicroRNAs - genetics ; Middle Aged ; Mortality ; Patients ; Prognosis ; Risk factors ; ROC Curve ; Schizophrenia ; Software ; Statistical analysis ; Stroke ; Stroke (Disease) ; Stroke - genetics ; Stroke - pathology ; Survival ; Survival analysis ; Survival Rate ; Traumatic brain injury</subject><ispartof>BioMed research international, 2021, Vol.2021 (1), p.4464945-4464945</ispartof><rights>Copyright © 2021 Hongtao Tian et al.</rights><rights>COPYRIGHT 2021 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2021 Hongtao Tian et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 Hongtao Tian et al. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-9612efa6e4fafba2c566ec4a5796d890ae168d18f004ab46af3a72b176f4eae53</citedby><cites>FETCH-LOGICAL-c476t-9612efa6e4fafba2c566ec4a5796d890ae168d18f004ab46af3a72b176f4eae53</cites><orcidid>0000-0002-5652-6402</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2609152312/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2609152312?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,4024,25753,27923,27924,27925,37012,37013,44590,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34901272$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Yang, Jun</contributor><contributor>Jun Yang</contributor><creatorcontrib>Tian, Hongtao</creatorcontrib><creatorcontrib>Zhao, Yan</creatorcontrib><creatorcontrib>Du, Chao</creatorcontrib><creatorcontrib>Zong, Xiao</creatorcontrib><creatorcontrib>Zhang, Xiuping</creatorcontrib><creatorcontrib>Qiao, Xia</creatorcontrib><title>Expression of miR-210, miR-137, and miR-153 in Patients with Acute Cerebral Infarction</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Aim. To explore the expression levels of miR-210, miR-137, and miR-153 in patients with acute cerebral infarction. Material and Methods. 76 patients with acute cerebral infarction treated in our hospital from April 2016 to October 2017 were enrolled as the observation group. Another 64 normal patients were selected as the control group. The patients were divided into the death and survival groups based on 1-year mortality of patients. qRT-PCR was used to detect the expression of miR-210, miR-137, and miR-153 in the serum of each group. Receiver operating characteristic (ROC) curve was employed to analyze the diagnostic value and predictive value of miR-210, miR-137 and miR-153 death in patients. The correlation between miR-210, miR-137, and miR-153 in the serum of the observation group was analyzed by Pearson’s test. Results. Levels of miR-210 and miR-137 in the observation group were significantly lower than those in the control group, while levels of miR-153 in the observation group were significantly higher than those in the control group (all P&lt;0.05). The ROC curve of diagnosis of acute cerebral infarction showed that the area under curve of miR-210 was 0.836, that of miR-137 was 0.843, and that of miR-153 was 0.842. The 1-year survival rate was 71.05%. The 1-year survival of the low-expression group of miR-210 and miR-137 was significantly lower than that of the high-expression group, while the 1-year survival of the low-expression group of miR-153 was significantly higher than that of the high-expression group (all P&lt;0.05). The ROC curve for predicting death showed that the area under curve of miR-210 was 0.786, that of miR-137 was 0.824, and that of miR-153 was 0.858. Pearson’s correlation analysis showed that the expression of miR-210 was positively correlated with that of miR-137, while miR-137 was negatively correlated with that of miR-153 and miR-210 was negatively correlated with that of miR-153. Conclusion. miR-210, miR-137, and miR-153 have a certain value in the diagnosis and prediction of 1-year death of acute cerebral infarction and may be potential diagnostic and predictive indicators.</description><subject>Acute Disease - mortality</subject><subject>Analysis</subject><subject>Brain Ischemia - genetics</subject><subject>Brain Ischemia - mortality</subject><subject>Brain Ischemia - pathology</subject><subject>Brain-derived neurotrophic factor</subject><subject>Care and treatment</subject><subject>Casualties</subject><subject>Cerebral infarction</subject><subject>Cerebral Infarction - genetics</subject><subject>Cerebral Infarction - mortality</subject><subject>Cerebral Infarction - pathology</subject><subject>Correlation analysis</subject><subject>Death</subject><subject>Diabetes</subject><subject>Diagnosis</subject><subject>Diagnostic systems</subject><subject>Female</subject><subject>Hospital patients</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Infarction</subject><subject>Male</subject><subject>Males</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Risk factors</subject><subject>ROC Curve</subject><subject>Schizophrenia</subject><subject>Software</subject><subject>Statistical analysis</subject><subject>Stroke</subject><subject>Stroke (Disease)</subject><subject>Stroke - genetics</subject><subject>Stroke - pathology</subject><subject>Survival</subject><subject>Survival analysis</subject><subject>Survival Rate</subject><subject>Traumatic brain injury</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNp9kcFvFCEUh4nR2Kb25tmQeDFxx_IYhhkuJptN1SZNNEa9kjcMdGlmYYWZVv97WXfdVA_CgUf48vHgR8hzYG8AmuaCMw4XQkihRPOInPIaRCVBwONjXdcn5DznW1ZGB5Ip-ZSc1EIx4C0_Jd8uf2yTzdnHQKOjG_-54sAWvwuo2wXFMOw3TU19oJ9w8jZMmd77aU2XZp4sXdlk-4QjvQoOk5mK6xl54nDM9vywnpGv7y6_rD5U1x_fX62W15URrZwqJYFbh9IKh65HbhoprRHYtEoOnWJoQXYDdI4xgb2Q6GpseQ-tdMKibeoz8nbv3c79xg6mtFYa0dvkN5h-6ohe_30S_FrfxDvdScmgU0Xw6iBI8fts86Q3Phs7jhhsnLPmEhhrOy54QV_-g97GOYXyvEIxBU358QfUDY5W--BiudfspHopVZlt8RVqsadMijkn644tA9O7ZPUuWX1ItuAvHj7zCP_JsQCv98DahwHv_f91vwA1eKcB</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Tian, Hongtao</creator><creator>Zhao, Yan</creator><creator>Du, Chao</creator><creator>Zong, Xiao</creator><creator>Zhang, Xiuping</creator><creator>Qiao, Xia</creator><general>Hindawi</general><general>John Wiley &amp; 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To explore the expression levels of miR-210, miR-137, and miR-153 in patients with acute cerebral infarction. Material and Methods. 76 patients with acute cerebral infarction treated in our hospital from April 2016 to October 2017 were enrolled as the observation group. Another 64 normal patients were selected as the control group. The patients were divided into the death and survival groups based on 1-year mortality of patients. qRT-PCR was used to detect the expression of miR-210, miR-137, and miR-153 in the serum of each group. Receiver operating characteristic (ROC) curve was employed to analyze the diagnostic value and predictive value of miR-210, miR-137 and miR-153 death in patients. The correlation between miR-210, miR-137, and miR-153 in the serum of the observation group was analyzed by Pearson’s test. Results. Levels of miR-210 and miR-137 in the observation group were significantly lower than those in the control group, while levels of miR-153 in the observation group were significantly higher than those in the control group (all P&lt;0.05). The ROC curve of diagnosis of acute cerebral infarction showed that the area under curve of miR-210 was 0.836, that of miR-137 was 0.843, and that of miR-153 was 0.842. The 1-year survival rate was 71.05%. The 1-year survival of the low-expression group of miR-210 and miR-137 was significantly lower than that of the high-expression group, while the 1-year survival of the low-expression group of miR-153 was significantly higher than that of the high-expression group (all P&lt;0.05). The ROC curve for predicting death showed that the area under curve of miR-210 was 0.786, that of miR-137 was 0.824, and that of miR-153 was 0.858. Pearson’s correlation analysis showed that the expression of miR-210 was positively correlated with that of miR-137, while miR-137 was negatively correlated with that of miR-153 and miR-210 was negatively correlated with that of miR-153. Conclusion. miR-210, miR-137, and miR-153 have a certain value in the diagnosis and prediction of 1-year death of acute cerebral infarction and may be potential diagnostic and predictive indicators.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>34901272</pmid><doi>10.1155/2021/4464945</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-5652-6402</orcidid><oa>free_for_read</oa></addata></record>
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subjects Acute Disease - mortality
Analysis
Brain Ischemia - genetics
Brain Ischemia - mortality
Brain Ischemia - pathology
Brain-derived neurotrophic factor
Care and treatment
Casualties
Cerebral infarction
Cerebral Infarction - genetics
Cerebral Infarction - mortality
Cerebral Infarction - pathology
Correlation analysis
Death
Diabetes
Diagnosis
Diagnostic systems
Female
Hospital patients
Humans
Hypertension
Infarction
Male
Males
Medical prognosis
Medical research
MicroRNA
MicroRNAs
MicroRNAs - genetics
Middle Aged
Mortality
Patients
Prognosis
Risk factors
ROC Curve
Schizophrenia
Software
Statistical analysis
Stroke
Stroke (Disease)
Stroke - genetics
Stroke - pathology
Survival
Survival analysis
Survival Rate
Traumatic brain injury
title Expression of miR-210, miR-137, and miR-153 in Patients with Acute Cerebral Infarction
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