The global epidemic of SARS‐CoV‐2 variants and their mutational immune escape

During the COVID‐19 pandemic, genetic variants of SARS‐CoV‐2 have been emerging and spreading around the world. Several SARS‐CoV‐2 endemic variants were found in United Kingdom, South Africa, Japan, and India between 2020 and April 2021. Studies have shown that many SARS‐CoV‐2 variants are more infe...

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Bibliographic Details
Published in:Journal of Medical Virology 2022-03, Vol.94 (3), p.847-857
Main Authors: Tian, Dandan, Sun, YanHong, Zhou, JianMing, Ye, Qing
Format: Article
Language:English
Subjects:
Amino acids
COVID-19
COVID-19 - epidemiology
COVID-19 Vaccines
Epidemics
Genetic diversity
Genetic variance
Humans
immune escape
Immune evasion
Mutation
mutations
Pandemics
Prevention
Review
Reviews
SARS-CoV-2 - genetics
SARS‐CoV‐2 variants
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Vaccines
Viral diseases
Virology
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Summary:During the COVID‐19 pandemic, genetic variants of SARS‐CoV‐2 have been emerging and spreading around the world. Several SARS‐CoV‐2 endemic variants were found in United Kingdom, South Africa, Japan, and India between 2020 and April 2021. Studies have shown that many SARS‐CoV‐2 variants are more infectious than early wild strain and produce immune escape. These SARS‐CoV‐2 variants have brought new challenges to the prevention and control of COVID‐19. This review summarizes and analyzes the biological characteristics of different amino acid mutations and the epidemic characteristics and immune escape of different SARS‐CoV‐2 variants. We hope to provide scientific reference for the monitoring, prevention, and control measures of new SARS‐CoV‐2 variants and the development strategy of the second‐generation vaccine.
ISSN:0146-6615
1096-9071
1096-9071
DOI:10.1002/jmv.27376