Genetic drift in the genome of SARS COV‐2 and its global health concern

The outbreak of the current coronavirus disease (COVID‐19) occurred in late 2019 and quickly spread all over the world. The severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) belongs to a genetically diverse group that mutates continuously leading to the emergence of multiple variants. Alt...

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Bibliographic Details
Published in:Journal of Medical Virology 2022-01, Vol.94 (1), p.88-98
Main Authors: Bano, Iqra, Sharif, Mehmoona, Alam, Sadia
Format: Article
Language:English
Subjects:
Antiviral agents
Coronaviruses
COVID-19
Genetic drift
genetics
Genomes
Global health
Inflammation
Mutation
Neutralizing
Pandemics
Public health
Review
Reviews
SARS‐CoV‐2
serodiagnosis
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
vaccination
Vaccines
variants
Viral diseases
Virology
Viruses
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Summary:The outbreak of the current coronavirus disease (COVID‐19) occurred in late 2019 and quickly spread all over the world. The severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) belongs to a genetically diverse group that mutates continuously leading to the emergence of multiple variants. Although a few antiviral agents and anti‐inflammatory medicines are available, thousands of individuals have passed away due to emergence of new viral variants. Thus, proper surveillance of the SARS‐CoV‐2 genome is needed for the rapid identification of developing mutations over time, which are of the major concern if they occur specifically in the surface spike proteins of the virus (neutralizing analyte). This article reviews the potential mutations acquired by the SARS‐CoV2 since the pandemic began and their significant impact on the neutralizing efficiency of vaccines and validity of the diagnostic assays.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.27337