Loading…
Coordinated cellular and humoral immune responses after two‐dose SARS‐CoV2 mRNA vaccination in liver transplant recipients
Limited data are available on risks and benefits of anti‐SARS‐CoV2 vaccination in solid organ transplant recipients, and weaker responses have been described. At the Italian National Institute for Infectious Diseases, 61 liver transplant recipients underwent testing to describe the dynamics of humor...
Saved in:
| Published in: | Liver international 2022-01, Vol.42 (1), p.180-186 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c5379-edc7fedc4e8b070f39d4d6dc5dbffb0b722e1b64412526fe6ec3485328d0fca3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c5379-edc7fedc4e8b070f39d4d6dc5dbffb0b722e1b64412526fe6ec3485328d0fca3 |
| container_end_page | 186 |
| container_issue | 1 |
| container_start_page | 180 |
| container_title | Liver international |
| container_volume | 42 |
| creator | D’Offizi, Gianpiero Agrati, Chiara Visco‐Comandini, Ubaldo Castilletti, Concetta Puro, Vincenzo Piccolo, Paola Montalbano, Marzia Meschi, Silvia Tartaglia, Eleonora Sorace, Chiara Leone, Sara Lapa, Daniele Grassi, Germana Goletti, Delia Ippolito, Giuseppe Vaia, Francesco Ettorre, Giuseppe Maria Lionetti, Raffaella |
| description | Limited data are available on risks and benefits of anti‐SARS‐CoV2 vaccination in solid organ transplant recipients, and weaker responses have been described. At the Italian National Institute for Infectious Diseases, 61 liver transplant recipients underwent testing to describe the dynamics of humoral and cell‐mediated immune response after two doses of anti‐SARS‐CoV2 mRNA vaccines and compared with 51 healthy controls. Humoral response was measured by quantifying both anti‐spike and neutralizing antibodies; cell‐mediated response was measured by PBMC proliferation assay with IFN‐γ and IL‐2 production. Liver transplant recipients showed lower response rates compared with controls in both humoral and cellular arms; shorter time since transplantation and multi‐drug immunosuppressive regimen containing mycophenolate mofetil were predictive of reduced response to vaccination. Specific antibody and cytokine production, though reduced, were highly correlated in transplant recipients. |
| doi_str_mv | 10.1111/liv.15089 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8662049</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2615066959</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5379-edc7fedc4e8b070f39d4d6dc5dbffb0b722e1b64412526fe6ec3485328d0fca3</originalsourceid><addsrcrecordid>eNp1kc9qFTEUxgex2Fpd-AIScGMXt82fmcxkI1wuVgsXhbZ0GzLJiU2ZScZk5pZuSh_BZ_RJzPTWiwpmkRzIl1--c76ieEPwMcnrpHObY1LhRjwrDkhZNwtGGXm-qynbL16mdIMxEaIiL4p9VtZEEFwfFPerEKJxXo1gkIaumzoVkfIGXU99iKpDru8nDyhCGoJPkJCyI0Q03oafDz9MSIAulucXuV6FK4r68y9LtFFaz0gXPHIeZXvzg6h8Gjrlx8zSbnDgx_Sq2LOqS_D66TwsLk8_Xq4-L9ZfP52tluuFrlgtFmB0bfNWQtPiGlsmTGm40ZVprW1xW1MKpOVlSWhFuQUOmpVNxWhjsNWKHRYftthhavvMyV_n1uQQXa_inQzKyb9vvLuW38JGNpxTXIoMeP8EiOH7BGmUvUvzuJSHMCVJK0EobhrCs_TdP9KbMEWfu5OU55Q4F9UMPNqqdAwpRbA7MwTLOVSZpyYfQ83at3-63yl_p5gFJ1vBrevg7v8kuT672iJ_AQa0sSU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2615066959</pqid></control><display><type>article</type><title>Coordinated cellular and humoral immune responses after two‐dose SARS‐CoV2 mRNA vaccination in liver transplant recipients</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>D’Offizi, Gianpiero ; Agrati, Chiara ; Visco‐Comandini, Ubaldo ; Castilletti, Concetta ; Puro, Vincenzo ; Piccolo, Paola ; Montalbano, Marzia ; Meschi, Silvia ; Tartaglia, Eleonora ; Sorace, Chiara ; Leone, Sara ; Lapa, Daniele ; Grassi, Germana ; Goletti, Delia ; Ippolito, Giuseppe ; Vaia, Francesco ; Ettorre, Giuseppe Maria ; Lionetti, Raffaella</creator><creatorcontrib>D’Offizi, Gianpiero ; Agrati, Chiara ; Visco‐Comandini, Ubaldo ; Castilletti, Concetta ; Puro, Vincenzo ; Piccolo, Paola ; Montalbano, Marzia ; Meschi, Silvia ; Tartaglia, Eleonora ; Sorace, Chiara ; Leone, Sara ; Lapa, Daniele ; Grassi, Germana ; Goletti, Delia ; Ippolito, Giuseppe ; Vaia, Francesco ; Ettorre, Giuseppe Maria ; Lionetti, Raffaella</creatorcontrib><description>Limited data are available on risks and benefits of anti‐SARS‐CoV2 vaccination in solid organ transplant recipients, and weaker responses have been described. At the Italian National Institute for Infectious Diseases, 61 liver transplant recipients underwent testing to describe the dynamics of humoral and cell‐mediated immune response after two doses of anti‐SARS‐CoV2 mRNA vaccines and compared with 51 healthy controls. Humoral response was measured by quantifying both anti‐spike and neutralizing antibodies; cell‐mediated response was measured by PBMC proliferation assay with IFN‐γ and IL‐2 production. Liver transplant recipients showed lower response rates compared with controls in both humoral and cellular arms; shorter time since transplantation and multi‐drug immunosuppressive regimen containing mycophenolate mofetil were predictive of reduced response to vaccination. Specific antibody and cytokine production, though reduced, were highly correlated in transplant recipients.</description><identifier>ISSN: 1478-3223</identifier><identifier>ISSN: 1478-3231</identifier><identifier>EISSN: 1478-3231</identifier><identifier>DOI: 10.1111/liv.15089</identifier><identifier>PMID: 34719107</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Antibodies ; Antibodies, Viral ; anti‐spike titre ; Brief Definitive Report ; Cirrhosis, Liver Failure and Transplantation ; COVID-19 - prevention & control ; COVID-19 Vaccines ; Cytokines ; Humans ; Immune response ; Immune response (humoral) ; Immune system ; Immunity, Humoral ; Immunosuppressive agents ; Infectious diseases ; Interferon ; Leukocytes, Mononuclear ; Liver ; Liver diseases ; liver transplant ; Liver Transplantation ; Liver transplants ; mRNA ; Mycophenolate mofetil ; Mycophenolic acid ; Peripheral blood mononuclear cells ; RNA, Messenger ; RNA, Viral ; SARS-CoV-2 ; SARS‐CoV2 vaccination ; Severe acute respiratory syndrome ; Transplant Recipients ; Transplantation ; T‐cell immune response ; Vaccination ; Vaccines</subject><ispartof>Liver international, 2022-01, Vol.42 (1), p.180-186</ispartof><rights>2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>2022 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5379-edc7fedc4e8b070f39d4d6dc5dbffb0b722e1b64412526fe6ec3485328d0fca3</citedby><cites>FETCH-LOGICAL-c5379-edc7fedc4e8b070f39d4d6dc5dbffb0b722e1b64412526fe6ec3485328d0fca3</cites><orcidid>0000-0003-0291-4490 ; 0000-0001-5773-7781 ; 0000-0003-2827-4591 ; 0000-0002-4810-1746 ; 0000-0002-7744-0683 ; 0000-0002-7501-5472 ; 0000-0003-0460-8024 ; 0000-0003-0924-993X ; 0000-0002-5252-0927 ; 0000-0002-0091-3585 ; 0000-0001-8168-8721 ; 0000-0002-1076-2979 ; 0000-0001-8360-4376 ; 0000-0002-4514-8776</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34719107$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>D’Offizi, Gianpiero</creatorcontrib><creatorcontrib>Agrati, Chiara</creatorcontrib><creatorcontrib>Visco‐Comandini, Ubaldo</creatorcontrib><creatorcontrib>Castilletti, Concetta</creatorcontrib><creatorcontrib>Puro, Vincenzo</creatorcontrib><creatorcontrib>Piccolo, Paola</creatorcontrib><creatorcontrib>Montalbano, Marzia</creatorcontrib><creatorcontrib>Meschi, Silvia</creatorcontrib><creatorcontrib>Tartaglia, Eleonora</creatorcontrib><creatorcontrib>Sorace, Chiara</creatorcontrib><creatorcontrib>Leone, Sara</creatorcontrib><creatorcontrib>Lapa, Daniele</creatorcontrib><creatorcontrib>Grassi, Germana</creatorcontrib><creatorcontrib>Goletti, Delia</creatorcontrib><creatorcontrib>Ippolito, Giuseppe</creatorcontrib><creatorcontrib>Vaia, Francesco</creatorcontrib><creatorcontrib>Ettorre, Giuseppe Maria</creatorcontrib><creatorcontrib>Lionetti, Raffaella</creatorcontrib><title>Coordinated cellular and humoral immune responses after two‐dose SARS‐CoV2 mRNA vaccination in liver transplant recipients</title><title>Liver international</title><addtitle>Liver Int</addtitle><description>Limited data are available on risks and benefits of anti‐SARS‐CoV2 vaccination in solid organ transplant recipients, and weaker responses have been described. At the Italian National Institute for Infectious Diseases, 61 liver transplant recipients underwent testing to describe the dynamics of humoral and cell‐mediated immune response after two doses of anti‐SARS‐CoV2 mRNA vaccines and compared with 51 healthy controls. Humoral response was measured by quantifying both anti‐spike and neutralizing antibodies; cell‐mediated response was measured by PBMC proliferation assay with IFN‐γ and IL‐2 production. Liver transplant recipients showed lower response rates compared with controls in both humoral and cellular arms; shorter time since transplantation and multi‐drug immunosuppressive regimen containing mycophenolate mofetil were predictive of reduced response to vaccination. Specific antibody and cytokine production, though reduced, were highly correlated in transplant recipients.</description><subject>Antibodies</subject><subject>Antibodies, Viral</subject><subject>anti‐spike titre</subject><subject>Brief Definitive Report</subject><subject>Cirrhosis, Liver Failure and Transplantation</subject><subject>COVID-19 - prevention & control</subject><subject>COVID-19 Vaccines</subject><subject>Cytokines</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune response (humoral)</subject><subject>Immune system</subject><subject>Immunity, Humoral</subject><subject>Immunosuppressive agents</subject><subject>Infectious diseases</subject><subject>Interferon</subject><subject>Leukocytes, Mononuclear</subject><subject>Liver</subject><subject>Liver diseases</subject><subject>liver transplant</subject><subject>Liver Transplantation</subject><subject>Liver transplants</subject><subject>mRNA</subject><subject>Mycophenolate mofetil</subject><subject>Mycophenolic acid</subject><subject>Peripheral blood mononuclear cells</subject><subject>RNA, Messenger</subject><subject>RNA, Viral</subject><subject>SARS-CoV-2</subject><subject>SARS‐CoV2 vaccination</subject><subject>Severe acute respiratory syndrome</subject><subject>Transplant Recipients</subject><subject>Transplantation</subject><subject>T‐cell immune response</subject><subject>Vaccination</subject><subject>Vaccines</subject><issn>1478-3223</issn><issn>1478-3231</issn><issn>1478-3231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1kc9qFTEUxgex2Fpd-AIScGMXt82fmcxkI1wuVgsXhbZ0GzLJiU2ZScZk5pZuSh_BZ_RJzPTWiwpmkRzIl1--c76ieEPwMcnrpHObY1LhRjwrDkhZNwtGGXm-qynbL16mdIMxEaIiL4p9VtZEEFwfFPerEKJxXo1gkIaumzoVkfIGXU99iKpDru8nDyhCGoJPkJCyI0Q03oafDz9MSIAulucXuV6FK4r68y9LtFFaz0gXPHIeZXvzg6h8Gjrlx8zSbnDgx_Sq2LOqS_D66TwsLk8_Xq4-L9ZfP52tluuFrlgtFmB0bfNWQtPiGlsmTGm40ZVprW1xW1MKpOVlSWhFuQUOmpVNxWhjsNWKHRYftthhavvMyV_n1uQQXa_inQzKyb9vvLuW38JGNpxTXIoMeP8EiOH7BGmUvUvzuJSHMCVJK0EobhrCs_TdP9KbMEWfu5OU55Q4F9UMPNqqdAwpRbA7MwTLOVSZpyYfQ83at3-63yl_p5gFJ1vBrevg7v8kuT672iJ_AQa0sSU</recordid><startdate>202201</startdate><enddate>202201</enddate><creator>D’Offizi, Gianpiero</creator><creator>Agrati, Chiara</creator><creator>Visco‐Comandini, Ubaldo</creator><creator>Castilletti, Concetta</creator><creator>Puro, Vincenzo</creator><creator>Piccolo, Paola</creator><creator>Montalbano, Marzia</creator><creator>Meschi, Silvia</creator><creator>Tartaglia, Eleonora</creator><creator>Sorace, Chiara</creator><creator>Leone, Sara</creator><creator>Lapa, Daniele</creator><creator>Grassi, Germana</creator><creator>Goletti, Delia</creator><creator>Ippolito, Giuseppe</creator><creator>Vaia, Francesco</creator><creator>Ettorre, Giuseppe Maria</creator><creator>Lionetti, Raffaella</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0291-4490</orcidid><orcidid>https://orcid.org/0000-0001-5773-7781</orcidid><orcidid>https://orcid.org/0000-0003-2827-4591</orcidid><orcidid>https://orcid.org/0000-0002-4810-1746</orcidid><orcidid>https://orcid.org/0000-0002-7744-0683</orcidid><orcidid>https://orcid.org/0000-0002-7501-5472</orcidid><orcidid>https://orcid.org/0000-0003-0460-8024</orcidid><orcidid>https://orcid.org/0000-0003-0924-993X</orcidid><orcidid>https://orcid.org/0000-0002-5252-0927</orcidid><orcidid>https://orcid.org/0000-0002-0091-3585</orcidid><orcidid>https://orcid.org/0000-0001-8168-8721</orcidid><orcidid>https://orcid.org/0000-0002-1076-2979</orcidid><orcidid>https://orcid.org/0000-0001-8360-4376</orcidid><orcidid>https://orcid.org/0000-0002-4514-8776</orcidid></search><sort><creationdate>202201</creationdate><title>Coordinated cellular and humoral immune responses after two‐dose SARS‐CoV2 mRNA vaccination in liver transplant recipients</title><author>D’Offizi, Gianpiero ; Agrati, Chiara ; Visco‐Comandini, Ubaldo ; Castilletti, Concetta ; Puro, Vincenzo ; Piccolo, Paola ; Montalbano, Marzia ; Meschi, Silvia ; Tartaglia, Eleonora ; Sorace, Chiara ; Leone, Sara ; Lapa, Daniele ; Grassi, Germana ; Goletti, Delia ; Ippolito, Giuseppe ; Vaia, Francesco ; Ettorre, Giuseppe Maria ; Lionetti, Raffaella</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5379-edc7fedc4e8b070f39d4d6dc5dbffb0b722e1b64412526fe6ec3485328d0fca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antibodies</topic><topic>Antibodies, Viral</topic><topic>anti‐spike titre</topic><topic>Brief Definitive Report</topic><topic>Cirrhosis, Liver Failure and Transplantation</topic><topic>COVID-19 - prevention & control</topic><topic>COVID-19 Vaccines</topic><topic>Cytokines</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune response (humoral)</topic><topic>Immune system</topic><topic>Immunity, Humoral</topic><topic>Immunosuppressive agents</topic><topic>Infectious diseases</topic><topic>Interferon</topic><topic>Leukocytes, Mononuclear</topic><topic>Liver</topic><topic>Liver diseases</topic><topic>liver transplant</topic><topic>Liver Transplantation</topic><topic>Liver transplants</topic><topic>mRNA</topic><topic>Mycophenolate mofetil</topic><topic>Mycophenolic acid</topic><topic>Peripheral blood mononuclear cells</topic><topic>RNA, Messenger</topic><topic>RNA, Viral</topic><topic>SARS-CoV-2</topic><topic>SARS‐CoV2 vaccination</topic><topic>Severe acute respiratory syndrome</topic><topic>Transplant Recipients</topic><topic>Transplantation</topic><topic>T‐cell immune response</topic><topic>Vaccination</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>D’Offizi, Gianpiero</creatorcontrib><creatorcontrib>Agrati, Chiara</creatorcontrib><creatorcontrib>Visco‐Comandini, Ubaldo</creatorcontrib><creatorcontrib>Castilletti, Concetta</creatorcontrib><creatorcontrib>Puro, Vincenzo</creatorcontrib><creatorcontrib>Piccolo, Paola</creatorcontrib><creatorcontrib>Montalbano, Marzia</creatorcontrib><creatorcontrib>Meschi, Silvia</creatorcontrib><creatorcontrib>Tartaglia, Eleonora</creatorcontrib><creatorcontrib>Sorace, Chiara</creatorcontrib><creatorcontrib>Leone, Sara</creatorcontrib><creatorcontrib>Lapa, Daniele</creatorcontrib><creatorcontrib>Grassi, Germana</creatorcontrib><creatorcontrib>Goletti, Delia</creatorcontrib><creatorcontrib>Ippolito, Giuseppe</creatorcontrib><creatorcontrib>Vaia, Francesco</creatorcontrib><creatorcontrib>Ettorre, Giuseppe Maria</creatorcontrib><creatorcontrib>Lionetti, Raffaella</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Liver international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>D’Offizi, Gianpiero</au><au>Agrati, Chiara</au><au>Visco‐Comandini, Ubaldo</au><au>Castilletti, Concetta</au><au>Puro, Vincenzo</au><au>Piccolo, Paola</au><au>Montalbano, Marzia</au><au>Meschi, Silvia</au><au>Tartaglia, Eleonora</au><au>Sorace, Chiara</au><au>Leone, Sara</au><au>Lapa, Daniele</au><au>Grassi, Germana</au><au>Goletti, Delia</au><au>Ippolito, Giuseppe</au><au>Vaia, Francesco</au><au>Ettorre, Giuseppe Maria</au><au>Lionetti, Raffaella</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coordinated cellular and humoral immune responses after two‐dose SARS‐CoV2 mRNA vaccination in liver transplant recipients</atitle><jtitle>Liver international</jtitle><addtitle>Liver Int</addtitle><date>2022-01</date><risdate>2022</risdate><volume>42</volume><issue>1</issue><spage>180</spage><epage>186</epage><pages>180-186</pages><issn>1478-3223</issn><issn>1478-3231</issn><eissn>1478-3231</eissn><abstract>Limited data are available on risks and benefits of anti‐SARS‐CoV2 vaccination in solid organ transplant recipients, and weaker responses have been described. At the Italian National Institute for Infectious Diseases, 61 liver transplant recipients underwent testing to describe the dynamics of humoral and cell‐mediated immune response after two doses of anti‐SARS‐CoV2 mRNA vaccines and compared with 51 healthy controls. Humoral response was measured by quantifying both anti‐spike and neutralizing antibodies; cell‐mediated response was measured by PBMC proliferation assay with IFN‐γ and IL‐2 production. Liver transplant recipients showed lower response rates compared with controls in both humoral and cellular arms; shorter time since transplantation and multi‐drug immunosuppressive regimen containing mycophenolate mofetil were predictive of reduced response to vaccination. Specific antibody and cytokine production, though reduced, were highly correlated in transplant recipients.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34719107</pmid><doi>10.1111/liv.15089</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-0291-4490</orcidid><orcidid>https://orcid.org/0000-0001-5773-7781</orcidid><orcidid>https://orcid.org/0000-0003-2827-4591</orcidid><orcidid>https://orcid.org/0000-0002-4810-1746</orcidid><orcidid>https://orcid.org/0000-0002-7744-0683</orcidid><orcidid>https://orcid.org/0000-0002-7501-5472</orcidid><orcidid>https://orcid.org/0000-0003-0460-8024</orcidid><orcidid>https://orcid.org/0000-0003-0924-993X</orcidid><orcidid>https://orcid.org/0000-0002-5252-0927</orcidid><orcidid>https://orcid.org/0000-0002-0091-3585</orcidid><orcidid>https://orcid.org/0000-0001-8168-8721</orcidid><orcidid>https://orcid.org/0000-0002-1076-2979</orcidid><orcidid>https://orcid.org/0000-0001-8360-4376</orcidid><orcidid>https://orcid.org/0000-0002-4514-8776</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1478-3223 |
| ispartof | Liver international, 2022-01, Vol.42 (1), p.180-186 |
| issn | 1478-3223 1478-3231 1478-3231 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8662049 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Antibodies Antibodies, Viral anti‐spike titre Brief Definitive Report Cirrhosis, Liver Failure and Transplantation COVID-19 - prevention & control COVID-19 Vaccines Cytokines Humans Immune response Immune response (humoral) Immune system Immunity, Humoral Immunosuppressive agents Infectious diseases Interferon Leukocytes, Mononuclear Liver Liver diseases liver transplant Liver Transplantation Liver transplants mRNA Mycophenolate mofetil Mycophenolic acid Peripheral blood mononuclear cells RNA, Messenger RNA, Viral SARS-CoV-2 SARS‐CoV2 vaccination Severe acute respiratory syndrome Transplant Recipients Transplantation T‐cell immune response Vaccination Vaccines |
| title | Coordinated cellular and humoral immune responses after two‐dose SARS‐CoV2 mRNA vaccination in liver transplant recipients |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T20%3A10%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Coordinated%20cellular%20and%20humoral%20immune%20responses%20after%20two%E2%80%90dose%20SARS%E2%80%90CoV2%20mRNA%20vaccination%20in%20liver%20transplant%20recipients&rft.jtitle=Liver%20international&rft.au=D%E2%80%99Offizi,%20Gianpiero&rft.date=2022-01&rft.volume=42&rft.issue=1&rft.spage=180&rft.epage=186&rft.pages=180-186&rft.issn=1478-3223&rft.eissn=1478-3231&rft_id=info:doi/10.1111/liv.15089&rft_dat=%3Cproquest_pubme%3E2615066959%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c5379-edc7fedc4e8b070f39d4d6dc5dbffb0b722e1b64412526fe6ec3485328d0fca3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2615066959&rft_id=info:pmid/34719107&rfr_iscdi=true |