Cerebral dominance in an unusual case of Landau-Kleffner syndrome

Landau-Kleffner syndrome (LKS) is described by the International Classification of Epileptic Syndromes since 1985 as a constellation of clinical and electrographic signs, including acquired aphasia, regression of language milestones and seizures, along with sleep-activated paroxysms on electroenceph...

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Bibliographic Details
Published in:BMJ case reports 2021-12, Vol.14 (12), p.e246696
Main Authors: Chowdhury, Nodee, Bansal, Atma Ram, Goyal, Rajeev, Nikhila, Gowathi
Format: Article
Language:English
Subjects:
Age
Aphasia
Case Report
Case reports
Child
Children & youth
Convulsions & seizures
Dominance, Cerebral
Electroencephalography
Epilepsy
Handedness
Humans
Landau-Kleffner Syndrome - diagnosis
Language
Male
Pathology
Patients
Seizures - etiology
Sleep
Speaking
Speech
Status Epilepticus - diagnosis
Status Epilepticus - drug therapy
Tomography
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Description
Summary:Landau-Kleffner syndrome (LKS) is described by the International Classification of Epileptic Syndromes since 1985 as a constellation of clinical and electrographic signs, including acquired aphasia, regression of language milestones and seizures, along with sleep-activated paroxysms on electroencephalogram which can progress to electrographic status epilepticus of sleep. In this case, a 7-year-old boy presented with an atypical history of new-onset aphasia and regression of language milestones with rare seizures. However, there was an electrographic mismatch in the form of right-sided epileptiform activity and continuous spike and wave of sleep pattern. Detailed speech analysis and perusal of the history revealed a possibly ambidextrous child with right hemispheric language dominance, and he was diagnosed with LKS and treated. This report illustrates the many pitfalls in the diagnosis and treatment of this rare epileptic syndrome.
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr-2021-246696