Comparison of thyroid-stimulating hormone levels in adolescents with schizophrenia, bipolar disorder, unipolar depression, conduct disorders, and hyperkinetic disorders

• Published in: Medicine (Baltimore) 2021-12, Vol.100 (49), p.e28160-e28160
• Main Authors: Makarow-Gronert, Agnieszka, Margulska, Aleksandra, Strzelecki, Dominik, Krajewska, Katarzyna, Gmitrowicz, Agnieszka, Gawlik-Kotelnicka, Oliwia
• Format: Article
• Language: English
• Subjects: Adolescent; Biomarkers - blood; Bipolar Disorder - blood; Bipolar Disorder - diagnosis; Bipolar Disorder - drug therapy; Child; Conduct Disorder - blood; Conduct Disorder - diagnosis; Conduct Disorder - drug therapy; Depressive Disorder - blood; Depressive Disorder - diagnosis; Depressive Disorder - drug therapy; Female; Humans; Lithium - therapeutic use; Male; Observational Study; Retrospective Studies; Schizophrenia - blood; Schizophrenia - diagnosis; Schizophrenia - drug therapy; Thyrotropin - blood
• ISSN: 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000028160

The aim of this study was to retrospectively compare values of thyroid-stimulating hormone (TSH) in adolescent patients diagnosed with schizophrenia, bipolar disorder, unipolar depression (UNI-DEP), conduct disorders (CD), and hyperkinetic disorders.The research involved 1122 patients (718 women, 64%); aged 12 to 18 hospitalized in the Department of Adolescent Psychiatry, Medical University of Lodz. We analyzed TSH levels in the whole study population and compared it between the above-mentioned subgroups of diagnoses.Mean serum TSH concentration in the studied population (n = 1122) was 2.06 μIU/mL. The values of percentiles were as follows: 2.5th - 0.53 μIU/mL, 10th - 0.89 μIU/mL, 25th - 1.31 μIU/mL, 50th - 1.9 μIU/mL, 75th - 2.6 μIU/mL, 90th - 3.43 μIU/mL, 97.5th - 4.72 μIU/mL. TSH values were negatively correlated with patients' age (P = .00001). Patients with bipolar depression had higher TSH levels than patients with CD (P = .002). Also, when male and female groups were examined separately we found that female patients with UNI-DEP and bipolar disorder had higher TSH levels than female patients with CD (P = .001; P = .001).Our results confirm that there may be a higher prevalence of thyroid dysfunctions in bipolar and UNI-DEP subgroups among adolescents and that it is worthy to consider some kind of interventions regarding thyroid function in depressed individuals.