Glyceryl trinitrate for the treatment of ischaemic stroke: Determining efficacy in rodent and ovine species for enhanced clinical translation

Hypertension is a leading risk factor for death and dependency after ischaemic stroke. However, administering anti-hypertensive medications post-stroke remains contentious with concerns regarding deleterious effects on cerebral blood flow and infarct expansion. This study sought to determine the eff...

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Bibliographic Details
Published in:Journal of cerebral blood flow and metabolism 2021-12, Vol.41 (12), p.3248-3259
Main Authors: Sorby-Adams, Annabel J, Learoyd, Annastazia E, Bath, Philip M, Burrows, Fiona, Farr, Tracy D, Leonard, Anna V, Schiessl, Ingo, Allan, Stuart M, Turner, Renée J, Trueman, Rebecca C
Format: Article
Language:English
Subjects:
Animals
Cerebrovascular Circulation - drug effects
Female
Ischemic Stroke - drug therapy
Ischemic Stroke - physiopathology
Male
Mice
Nitroglycerin - pharmacology
Original
Sheep
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Summary:Hypertension is a leading risk factor for death and dependency after ischaemic stroke. However, administering anti-hypertensive medications post-stroke remains contentious with concerns regarding deleterious effects on cerebral blood flow and infarct expansion. This study sought to determine the effect of glyceryl trinitrate (GTN) treatment in both lissencephalic and gyrencephalic pre-clinical stroke models. Merino sheep underwent middle cerebral artery occlusion (MCAO) followed by GTN or control patch administration (0.2 mg/h). Monitoring of numerous physiologically relevant measures over 24 h showed that GTN administration was associated with decreased intracranial pressure, infarct volume, cerebral oedema and midline shift compared to vehicle treatment (p 
ISSN:0271-678X
1559-7016
DOI:10.1177/0271678X211018901