COVID-19: Invasion, pathogenesis and possible cure – A review

• Published in: Journal of virological methods 2022-02, Vol.300, p.114434-114434, Article 114434
• Main Authors: P, Nitin, R., Nandhakumar, B., Vidhya, S., Rajesh, A., Sakunthala
• Format: Article
• Language: English
• Subjects: Animals; China - epidemiology; Coronavirus; COVID-19; Humans; Invasion; Pandemics; Pathogenesis; Public Health; SARS-CoV-2; Vaccine
• ISSN: 0166-0934; 1879-0984
• DOI: 10.1016/j.jviromet.2021.114434

•The major entry molecules for the invasion of Coronavirus into the host cell has been discussed.•The pathogenesis due to the invasion of coronavirus through the major pathways has been elaborated.•Reasoning, and justification on the usage of several available vaccines based on their limitations has been detailed.•The efforts towards possible cure in terms of vaccine development and precautions are highlighted. Today, Coronavirus disease (COVID-19) which is believed to be transmitted from bats to humans where the people of Wuhan city, China exposed to the wet animal market is an important international public health anxiety (Xiong et al., 2020). Although, several measures were undertaken to treat the diseases by various medical advancements and by a variety of treatment procedures, still the mortality is higher. Hence, social distancing has been implemented to control the current outburst of this pandemic which spreads through human to human transmission. As a consequence, there is a need to completely understand the route of invasions of the virus into the humans and the target receptors besides the other factors leading to the disease. Several vaccines and drugs have been developed with its own pros and cons. Many are still under the various phase of R&D and clinical trials. Here we highlight the possible entry molecules, pathogenesis, symptomatology, probable cure and the recently developed vaccines for the existing pandemic due to the COVID-19.