Longitudinal DNA methylation dynamics as a practical indicator in clinical epigenetics

One of the fundamental assumptions of DNA methylation in clinical epigenetics is that DNA methylation status can change over time with or without interplay with environmental and clinical conditions. However, little is known about how DNA methylation status changes over time under ordinary environme...

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Published in:Clinical epigenetics 2021-12, Vol.13 (1), p.219-219, Article 219
Main Authors: Komaki, Shohei, Ohmomo, Hideki, Hachiya, Tsuyoshi, Sutoh, Yoichi, Ono, Kanako, Furukawa, Ryohei, Umekage, So, Otsuka-Yamasaki, Yayoi, Tanno, Kozo, Sasaki, Makoto, Shimizu, Atsushi
Format: Article
Language:English
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Blood
Datasets
Deoxyribonucleic acid
DNA
DNA methylation
DNA Methylation - genetics
Epigenetic inheritance
Epigenetics
Epigenomics - methods
Epigenomics - standards
Gene expression
Genetic research
Genomes
Humans
Inflammation
Methylation
Neutrophils
Regression analysis
Variance analysis
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Summary:One of the fundamental assumptions of DNA methylation in clinical epigenetics is that DNA methylation status can change over time with or without interplay with environmental and clinical conditions. However, little is known about how DNA methylation status changes over time under ordinary environmental and clinical conditions. In this study, we revisited the high frequency longitudinal DNA methylation data of two Japanese males (24 time-points within three months) and characterized the longitudinal dynamics. The results showed that the majority of CpGs on Illumina HumanMethylation450 BeadChip probe set were longitudinally stable over the time period of three months. Focusing on dynamic and stable CpGs extracted from datasets, dynamic CpGs were more likely to be reported as epigenome-wide association study (EWAS) markers of various traits, especially those of immune- and inflammatory-related traits; meanwhile, the stable CpGs were enriched in metabolism-related genes and were less likely to be EWAS markers, indicating that the stable CpGs are stable both in the short-term within individuals and under various environmental and clinical conditions. This study indicates that CpGs with different stabilities are involved in different functions and traits, and thus, they are potential indicators that can be applied for clinical epigenetic studies to outline underlying mechanisms.
ISSN:1868-7075
1868-7083
1868-7083
1868-7075
DOI:10.1186/s13148-021-01202-6