Improvement of Coronary Microvascular Function After Angiotensin Receptor Blocker Treatment With Irbesartan in Patients With Systemic Hypertension

Patients with hypertension exhibit changes in vessel conductance and resistance. The aim of this study was to evaluate the effect of the angiotensin receptor blocker irbesartan on coronary microvascular function. Thirty‐six hypertensive patients without coronary artery or systemic disease were exami...

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Bibliographic Details
Published in:The journal of clinical hypertension (Greenwich, Conn.) Conn.), 2011-03, Vol.13 (3), p.155-161
Main Authors: Lethen, Harald, Tries, Hans‐Peter, Kersting, Stefan, Bramlage, Peter, Lambertz, Heinz
Format: Article
Language:English
Subjects:
Angiotensin II Type 1 Receptor Blockers - therapeutic use
Antihypertensive Agents - therapeutic use
Biomarkers
Biphenyl Compounds - therapeutic use
Blood Flow Velocity
Carotid Arteries - diagnostic imaging
Carotid Arteries - pathology
Case-Control Studies
Coronary Circulation
Echocardiography
Electrocardiography, Ambulatory
Humans
hypertension
Hypertension - diagnostic imaging
Hypertension - drug therapy
Irbesartan
Male
Microvessels - diagnostic imaging
Microvessels - drug effects
Middle Aged
Original Paper
Original Papers
Renin-Angiotensin System - drug effects
Risk Factors
Tetrazoles - therapeutic use
Velocity
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Summary:Patients with hypertension exhibit changes in vessel conductance and resistance. The aim of this study was to evaluate the effect of the angiotensin receptor blocker irbesartan on coronary microvascular function. Thirty‐six hypertensive patients without coronary artery or systemic disease were examined. Coronary flow velocity reserve (CFR) was measured using transthoracic Doppler echocardiography in 18 men (54±9 years) before and after 3 months of treatment with 600 mg/d of irbesartan and in 18 controls (55±11 years). Carotid intima‐media thickness (IMT) was evaluated with high‐resolution echocardiography. Baseline CFR did not differ between groups. CFR significantly improved in the irbesartan group (from 2.87±.42 to 3.78±.32; P
ISSN:1524-6175
1751-7176
DOI:10.1111/j.1751-7176.2010.00401.x