Misexpression of genes lacking CpG islands drives degenerative changes during aging

Cellular aging is characterized by disruption of the nuclear lamina and its associated heterochromatin. How these structural changes within the nucleus contribute to age-related degeneration of the organism is unclear. Genes lacking CpG islands (CGI genes) generally associate with heterochromatin wh...

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Published in:Science advances 2021-12, Vol.7 (51), p.eabj9111-eabj9111
Main Authors: Lee, Jun-Yeong, Davis, Ian, Youth, Elliot H H, Kim, Jonghwan, Churchill, Gary, Godwin, James, Korstanje, Ron, Beck, Samuel
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Language:English
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Biomedicine and Life Sciences
Diseases and Disorders
SciAdv r-articles
Systems Biology
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cited_by cdi_FETCH-LOGICAL-c456t-246d738e799da0da8946f1d7611da6bdcfe25f12f07d02c96db4b8201057620a3
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container_issue 51
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container_title Science advances
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creator Lee, Jun-Yeong
Davis, Ian
Youth, Elliot H H
Kim, Jonghwan
Churchill, Gary
Godwin, James
Korstanje, Ron
Beck, Samuel
description Cellular aging is characterized by disruption of the nuclear lamina and its associated heterochromatin. How these structural changes within the nucleus contribute to age-related degeneration of the organism is unclear. Genes lacking CpG islands (CGI genes) generally associate with heterochromatin when they are inactive. Here, we show that the expression of these genes is globally activated in aged cells and tissues. This CGI gene misexpression is a common feature of normal and pathological aging in mice and humans. We report evidence that CGI gene up-regulation is directly responsible for age-related physiological deterioration, notably for increased secretion of inflammatory mediators.
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subjects Biomedicine and Life Sciences
Diseases and Disorders
SciAdv r-articles
Systems Biology
title Misexpression of genes lacking CpG islands drives degenerative changes during aging
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