Changes in Circulating Kisspeptin Levels During Each Trimester in Women With Antenatal Complications

Antenatal complications such as hypertensive disorders of pregnancy (HDP), fetal growth restriction (FGR), gestational diabetes (GDM), and preterm birth (PTB) are associated with placental dysfunction. Kisspeptin has emerged as a putative marker of placental function, but limited data exist describi...

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Published in:The journal of clinical endocrinology and metabolism 2022-01, Vol.107 (1), p.e71-e83
Main Authors: Abbara, Ali, Al-Memar, Maya, Phylactou, Maria, Daniels, Elisabeth, Patel, Bijal, Eng, Pei C, Nadir, Rans, Izzi-Engbeaya, Chioma, Clarke, Sophie A, Mills, Edouard G, Hunjan, Tia, Pacuszka, Ewa, Yang, Lisa, Bech, Paul, Tan, Tricia, Comninos, Alexander N, Kelsey, Tom W, Kyriacou, Christopher, Fourie, Hanine, Bourne, Tom, Dhillo, Waljit S
Format: Article
Language:English
Subjects:
Adult
Analysis
Biomarkers - blood
Blood
Book publishing
Case-Control Studies
Diabetes, Gestational - physiopathology
Female
Fetal Growth Retardation - epidemiology
Fetal Growth Retardation - pathology
Fetus
Follow-Up Studies
Gestational Age
Growth
Humans
Hypertension
Hypertension, Pregnancy-Induced - epidemiology
Hypertension, Pregnancy-Induced - pathology
Infant, Newborn
Infants (Premature)
Kisspeptins - blood
London - epidemiology
Medical examination
Online Only
Placenta Diseases - epidemiology
Placenta Diseases - pathology
Pre-Eclampsia - physiopathology
Pregnancy
Pregnancy Trimesters
Premature Birth - epidemiology
Premature Birth - pathology
Prognosis
Women
Women in the book industry
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Summary:Antenatal complications such as hypertensive disorders of pregnancy (HDP), fetal growth restriction (FGR), gestational diabetes (GDM), and preterm birth (PTB) are associated with placental dysfunction. Kisspeptin has emerged as a putative marker of placental function, but limited data exist describing circulating kisspeptin levels across all 3 trimesters in women with antenatal complications. We aimed to assess whether kisspeptin levels are altered in women with antenatal complications. Women with antenatal complications (n = 105) and those with uncomplicated pregnancies (n = 265) underwent serial ultrasound scans and blood sampling at the Early Pregnancy Assessment Unit at Hammersmith Hospital, UK, at least once during each trimester (March 2014 to March 2017). The women with antenatal complications (HDP [n = 32], FGR [n = 17], GDM [n = 35], PTB [n = 11], and multiple complications [n=10]) provided 373 blood samples and the controls provided 930 samples. Differences in circulating kisspeptin levels were assessed. Third-trimester kisspeptin levels were higher than controls in HDP but lower in FGR. The odds of HDP adjusted for gestational age, maternal age, ethnicity, BMI, smoking, and parity were increased by 30% (95% CI, 16%-47%; P 
ISSN:0021-972X
1945-7197
1945-7197
DOI:10.1210/clinem/dgab617