The impact of resveratrol on skin wound healing, scarring, and aging

Resveratrol is a well‐known antioxidant that harbours many health beneficial properties. Multiple studies associated the antioxidant, anti‐inflammatory, and cell protective effects of resveratrol. These diverse effects of resveratrol are also potentially involved in cutaneous wound healing, scarring...

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Bibliographic Details
Published in:International wound journal 2022-01, Vol.19 (1), p.9-28
Main Authors: Hecker, Andrzej, Schellnegger, Marlies, Hofmann, Elisabeth, Luze, Hanna, Nischwitz, Sebastian Philipp, Kamolz, Lars‐Peter, Kotzbeck, Petra
Format: Article
Language:English
Subjects:
Aging
Angiogenesis
Antioxidants
Apoptosis
Bacteria
Body fat
Cell adhesion & migration
Cell culture
Cell growth
Cellulose
chronic wound
Cicatrix - drug therapy
Collagen
Fibroblasts
Glucose
Humans
Invited Review
Kinases
Oxidative stress
Phosphorylation
Polyphenols
Research Design
resveratrol
Resveratrol - therapeutic use
scarring
Scars
Skin
skin aging
Stem cells
Vascular endothelial growth factor
Wound healing
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Summary:Resveratrol is a well‐known antioxidant that harbours many health beneficial properties. Multiple studies associated the antioxidant, anti‐inflammatory, and cell protective effects of resveratrol. These diverse effects of resveratrol are also potentially involved in cutaneous wound healing, scarring, and (photo‐)aging of the skin. Hence, this review highlighted the most relevant studies involving resveratrol in wound healing, scarring, and photo‐aging of the skin. A systematic review was performed and the database PubMed was searched for suitable publications. Only original articles in English that investigated the effects of resveratrol in wound healing, scarring, and (photo‐)aging of the skin were analysed. The literature search yielded a total of 826 studies, but only 41 studies met the inclusion criteria. The included studies showed promising results that resveratrol might be a feasible treatment approach to support wound healing, counteract excessive scarring, and even prevent photo‐aging of the skin. Resveratrol represents an interesting and promising novel therapy regime but to confirm resveratrol‐associated effects, more evidence based in vitro and in vivo studies are needed.
ISSN:1742-4801
1742-481X
DOI:10.1111/iwj.13601