Placental development during early pregnancy: Effects of embryo origin on expression of chemokine ligand twelve (CXCL12)

Abstract The aim was to localize chemokine ligand twelve (CXCL12) in sheep placental tissues during early gestation and after assisted reproductive technologies (ART). Uteri were collected from naturally (NAT) mated ewes and ewes receiving embryo transfer (ET), in vitro fertilization (IVF) or in vit...

Full description

Saved in:
Bibliographic Details
Published in:Placenta (Eastbourne) 2016-07, Vol.43, p.77-80
Main Authors: Quinn, K.E, Reynolds, L.P, Grazul-Bilska, A.T, Borowicz, P.P, Ashley, R.L
Format: Article
Language:English
Subjects:
Animals
Assisted reproductive technologies
Chemokine CXCL12 - metabolism
CXCL12
Embryo Implantation - physiology
Embryo Transfer - veterinary
Female
Implantation
Internal Medicine
Obstetrics and Gynecology
Placenta - metabolism
Placentation
Placentation - physiology
Pregnancy
Reproductive Techniques, Assisted - veterinary
Sheep
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract The aim was to localize chemokine ligand twelve (CXCL12) in sheep placental tissues during early gestation and after assisted reproductive technologies (ART). Uteri were collected from naturally (NAT) mated ewes and ewes receiving embryo transfer (ET), in vitro fertilization (IVF) or in vitro activation (IVA). CXCL12 was immunolocalized to endometrial stroma, glands, and trophoblast. Greater CXCL12 immunoreactivity was present in trophoblast on day 22 and 24 and in NAT ewes compared to IVF and IVA. Increased CXCL12 expression suggests CXCL12 promotes implantation and placentation. Decreased CXCL12 in IVF and IVA embryos, may compromise pregnancy establishment when utilizing ART methods.
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2016.05.008