Sepsis, Cytokine Storms, and Immunopathology: The Divide between Neonates and Adults

Sepsis can result from a variety of pathogens, originating from a range of sources. A vast range of presenting symptoms is included in the catch-all term of "bacteremia," making diagnosis and prognosis particularly troublesome. One underexplored factor contributing to disparate outcomes is...

Full description

Saved in:
Bibliographic Details
Published in:ImmunoHorizons 2021-06, Vol.5 (6), p.512-522
Main Authors: Greenfield, Kara G, Badovinac, Vladimir P, Griffith, Thomas S, Knoop, Kathryn A
Format: Article
Language:English
Subjects:
Adult
Age Factors
Animals
Cytokine Release Syndrome - genetics
Cytokine Release Syndrome - immunology
Cytokine Release Syndrome - microbiology
Cytokine Release Syndrome - mortality
Disease Models, Animal
Disease Progression
Host-Pathogen Interactions - immunology
Humans
Infant, Newborn
Sepsis - genetics
Sepsis - immunology
Sepsis - microbiology
Sepsis - mortality
Severity of Illness Index
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Sepsis can result from a variety of pathogens, originating from a range of sources. A vast range of presenting symptoms is included in the catch-all term of "bacteremia," making diagnosis and prognosis particularly troublesome. One underexplored factor contributing to disparate outcomes is the age of the patient. Neonatal sepsis in very-low-birth-weight infants can result in vastly different immunological outcomes unique from sepsis in adults. It is also becoming increasingly clear, both from preclinical experimental models and clinical observations, that the age and history of previous microbial exposures can significantly influence the course of infection from sepsis and cytokine storms to immunopathology. In this study, we will explore key differences between neonatal and adult sepsis, experimental models used to study sepsis, and how responses to the surrounding microbial universe shape development of the immune system and impact, positively or negatively, the course of disease.
ISSN:2573-7732
2573-7732
DOI:10.4049/immunohorizons.2000104